Immune Thrombocytopenic Purpura in a Patient with Preexisting Ulcerative Colitis: A Case Report.
- Author:
Byeong Heon PARK
1
;
Hyo Jong KIM
;
Young Woon CHANG
;
Sun Kee MIN
;
Cheon Woong CHOI
;
Dong Keun LEE
;
Seok Ho DONG
;
Byung Ho KIM
;
Joung Il LEE
;
Rin CHANG
Author Information
1. Department of Internal Medicine, Kyeung Hee University College of Medicine, Seoul, Korea.
- Publication Type:Case Report
- Keywords:
Ulcerative colitis;
Immune thrombocytopenic purpura
- MeSH:
Adrenal Cortex Hormones;
Anemia, Hemolytic, Autoimmune;
Antibodies;
Bone Marrow Examination;
Colitis, Ulcerative*;
Humans;
Immunization;
Inflammatory Bowel Diseases;
Megakaryocytes;
Phenobarbital;
Plasmapheresis;
Purpura, Thrombocytopenic, Idiopathic*;
Splenectomy;
Thrombocytopenia;
Ulcer*
- From:Korean Journal of Gastrointestinal Endoscopy
2002;24(1):44-48
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Ulcerative colitis (UC) is a chronic inflammatory bowel disease with evidence of immune activation and is associated with extraintestinal diseases in numerous target tissues. Extraintestinal manifestations of UC are well described in numerous tissues, most notably mucotaneous, synovial, biliary, and opthalmic. Among hematological complications of UC, autoimmune hemolytic anemia is often reported, but immune-mediated thrombocytopenia (ITP) is rare. We present one case in which exacerbation of UC sequentially induced development of ITP. Platelet-associated antibodies were positive. Bone marrow examinations revealed increased megakaryocyte number. ITP was treated with corticosteroids, intravenous immune gamma- globulin and plasmapheresis. However, because previous treatments were not successful, splenectomy was done. This may provide further evidence that ITP is causally associated with UC, and is the result of immunostimulation from luminal antigens and altered immunoregulation.
