Rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) chemotherapy for diffuse large B-cell lymphoma in pregnancy may be associated with preterm birth.
10.5468/ogs.2014.57.6.526
- Author:
Eun Ju LEE
1
;
Ki Hoon AHN
;
Soon Cheol HONG
;
Eun Hee LEE
;
Yong PARK
;
Byung Soo KIM
Author Information
1. Department of Obstetrics and Gynecology, Korea University Medical Center, Korea University College of Medicine, Seoul, Korea. novak082@naver.com
- Publication Type:Case Report
- Keywords:
Chemotherapy;
Diffuse large B-cell lymphoma;
Pregnancy;
Preterm birth;
R-CHOP
- MeSH:
Cesarean Section;
Cyclophosphamide*;
Doxorubicin*;
Drug Therapy*;
Female;
Fetal Distress;
Follow-Up Studies;
Humans;
Lymphoma;
Lymphoma, B-Cell*;
Lymphoma, Non-Hodgkin;
Magnetic Resonance Imaging;
Prednisone*;
Pregnancy*;
Pregnant Women;
Premature Birth*;
Vincristine*;
Young Adult;
Rituximab
- From:Obstetrics & Gynecology Science
2014;57(6):526-529
- CountryRepublic of Korea
- Language:English
-
Abstract:
Lymphoma, especially non-Hodgkin's lymphoma is extremely rare in pregnancy. A 24-year-old pregnant woman was diagnosed with diffuse large B-cell lymphoma (DLBCL), a subgroup of non-Hodgkin's lymphoma, at 24 weeks' gestation, and was treated with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) chemotherapy. After 4 cycles of R-CHOP, she delivered a healthy baby via cesarean section at 34 weeks and 5 days' gestation because of preterm contraction-related fetal distress. The patient was administered the remaining 2 cycles of R-CHOP after delivery. Follow-up magnetic resonance imaging and computed tomography showed complete remission. Here, we report a rare case of DLBCL successfully treated with R-CHOP chemotherapy during pregnancy, we also performed a systematic review of literature for similar cases. There were 3 earlier reports of R-CHOP treatment for DLBCL. All cases, including our case, resulted in preterm birth. Together, these findings suggest that R-CHOP chemotherapy for DLBCL in pregnancy may be associated with preterm birth.
