Atherosclerotic Progression Attenuates the Expression of Nogo-B in Autopsied Coronary Artery: Pathology and Virtual Histology Intravascular Ultrasound Analysis.
10.3346/jkms.2009.24.4.596
- Author:
Wang Soo LEE
1
;
Sang Wook KIM
;
Soon Auck HONG
;
Tae Jin LEE
;
Eon Sub PARK
;
Hyoung Joong KIM
;
Kwang Je LEE
;
Tae Ho KIM
;
Chee Jeong KIM
;
Wang Seong RYU
Author Information
1. Department of Internal Medicine, College of Medicine, Chung-Ang University, Seoul, Korea. wslee1227@dreamwiz.com
- Publication Type:Original Article
- Keywords:
Atherosclerosis;
Nogo Protein;
Ultrasonography, Interventional;
Autopsy
- MeSH:
Adult;
Age Factors;
Coronary Artery Disease/*diagnosis/pathology/ultrasonography;
Coronary Vessels/*pathology/*ultrasonography;
Disease Progression;
Female;
Humans;
Male;
Middle Aged;
Myelin Proteins/*metabolism;
Ultrasonography, Interventional
- From:Journal of Korean Medical Science
2009;24(4):596-604
- CountryRepublic of Korea
- Language:English
-
Abstract:
The relation of Nogo-B to atherosclerotic plaque progression is not well understood. Thus, the purpose of this study was to assess the expression of Nogo-B in fibroatheromas (FA) of different stages, classified using virtual histology intravascular ultrasound (VH-IVUS) analysis in 19 autopsied cases of non-sudden cardiac death. VH-IVUS imaging analysis was performed 30 mm from the ostium of each coronary artery. VH-IVUS revealed 11 early FAs (34.5+/-8.3 yr), 12 late FAs (42.6+/-16.6 yr), 8 thick-cap FAs (TkCFAs) (46.4+/-11.1 yr), and 6 thin-cap FAs (TCFAs) (51.8+/-6.8 yr). TkCFAs and TCFAs were defined as advanced FA. FA progression advanced with age (P=0.04). VH-IVUS analysis of small, early FAs showed smaller necrotic cores and relatively less calcium compared to more advanced FAs with large necrotic cores (P<0.001). Histopathology and immunohistochemical stains demonstrated that early or late FAs had smaller necrotic cores, less empty space of decalcification, and greater Nogo-B expression compared to advanced FAs (vs. early FA, P=0.013; vs. late FA, P=0.008, respectively). These findings suggest that FA progression is inversely associated with Nogo-B expression. Local reduction of Nogo-B may contribute to plaque formation and/or instability.
