Interleukin-13 and Its Receptors in Idiopathic Interstitial Pneumonia: Clinical Implications for Lung Function.
10.3346/jkms.2009.24.4.614
- Author:
Sung Woo PARK
1
;
Mi Hyun AHN
;
Hee Kyung JANG
;
An Soo JANG
;
Do Jin KIM
;
Eun Suk KOH
;
Jong Sook PARK
;
Soo Taek UH
;
Yong Hoon KIM
;
Jai Soung PARK
;
Sang Hyun PAIK
;
Hwa Kyun SHIN
;
Wook YOUM
;
Choon Sik PARK
Author Information
1. Genome Research Center for Allergy and Respiratory Disease, Soonchunhyang University Bucheon Hospital, Bucheon, Korea. mdcspark@unitel.co.kr
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Interleukin-13;
Interleukin-13 Receptor Alpha1 Subunit;
Interleukin-13 Receptor Alpha2 Subunit;
Idiopathic Pulmonary Fibrosis;
Lung Function;
NSIP
- MeSH:
Adult;
Female;
Humans;
Idiopathic Interstitial Pneumonias/diagnosis/*metabolism;
Idiopathic Pulmonary Fibrosis/diagnosis/*metabolism;
Interferon-gamma/analysis;
Interleukin-13/*analysis;
Interleukin-13 Receptor alpha1 Subunit/*metabolism;
Interleukin-13 Receptor alpha2 Subunit/*metabolism;
Interleukin-4/analysis;
Lung/physiopathology;
Male;
Middle Aged
- From:Journal of Korean Medical Science
2009;24(4):614-620
- CountryRepublic of Korea
- Language:English
-
Abstract:
Idiopathic interstitial pneumonia (IIP) is characterized by varying degrees of interstitial fibrosis. IL-13 and IL-4 are strong inducers of tissue fibrosis, whereas IFN-gamma has antifibrotic potential. However, the roles of these substances in IIP remain unknown. IL-13, IL-4, and IFN-gamma were measured in the BAL fluid of 16 idiopathic pulmonary fibrosis (IPF) patients, 10 nonspecific interstitial pneumonia (NSIP) patients, and 8 normal controls. The expression of IL-13 and IL-13Ralpha1/alpha2 in lung tissues was analyzed using ELISA and immunohistochemistry. IL-13 levels were significantly higher in IPF patients than the others (P<0.05). IL-4 levels were higher in both IPF and NSIP patients than in normal controls (P<0.05), and IFN-gamma levels were lower in NSIP patients than in normal controls (P=0.047). IL-13 levels correlated inversely with FVC% (r=-0.47, P=0.043) and DLCO% (r=-0.58, P=0.014) in IPF and NSIP patients. IL-13 was strongly expressed in the smooth muscle, bronchial epithelium, alveolar macrophages and endothelium of IPF patients. IL-13Ralpha1, rather than IL-13Ralpha2, was strongly expressed in the smooth muscle, bronchial epithelium, and endothelium of IPF patients. IL-13 and its receptors may contribute to the pathogenesis of fibrosis in IIP and appear to be related to the severity of the disease.
