Nidogen Plays a Role in the Regenerative Axon Growth of Adult Sensory Neurons Through Schwann Cells.
10.3346/jkms.2009.24.4.654
- Author:
Hyun Kyoung LEE
1
;
In Ae SEO
;
Duk Joon SUH
;
Hwan Tae PARK
Author Information
1. Department of Physiology & Medical Science Research Institute, College of Medicine, Dong-A University, Busan, Korea. phwantae@dau.ac.kr
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Nidogen;
Neurites;
Regeneration;
Dorsal Root Ganglion;
Tumor Endothelial Marker 7;
Schwann Cells
- MeSH:
Animals;
Axotomy;
Cell Movement;
Cell Proliferation;
Male;
Membrane Glycoproteins/*physiology;
Membrane Proteins/pharmacology;
*Nerve Regeneration;
Nerve Tissue Proteins/pharmacology;
Neurites/drug effects/*physiology/ultrastructure;
Rats;
Rats, Sprague-Dawley;
Recombinant Proteins/pharmacology;
Schwann Cells/cytology/*physiology;
Sensory Receptor Cells/*physiology
- From:Journal of Korean Medical Science
2009;24(4):654-659
- CountryRepublic of Korea
- Language:English
-
Abstract:
We previously reported that nidogen is an extracellular matrix protein regulating Schwann cell proliferation and migration. Since Schwann cells play a critical role in peripheral nerve regeneration, nidogen may play a role in it via regulation of Schwann cells. Here, we demonstrate direct evidence that nidogen induces elongation of regenerative axon growth of adult sensory neurons, and that the effect is Schwann cell dependent. Continuous infusion of recombinant ectodomain of tumor endothelial marker 7, which specifically blocks nidogen function in Schwann cells, suppressed regenerative neurite growth in a sciatic nerve axotomy model. Taken together, it is likely that nidogen is required for proper regeneration of peripheral nerves after injury.
