Association of Plasma Levels of Resistin with Subcutaneous Fat Mass and Markers of Inflammation but not with Metabolic Determinants or Insulin Resistance.
10.3346/jkms.2009.24.4.695
- Author:
Jong Chul WON
1
;
Cheol Young PARK
;
Won Young LEE
;
Eon Sook LEE
;
Sang Woo OH
;
Sung Woo PARK
Author Information
1. Department of Internal Medicine, Sungkyunkwan University School of Medicine, Kangbuk Samsung Hospital, Seoul, Korea. cydoctor@chol.com
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Resistin;
Metabolic Syndrome;
C-reactive Protein
- MeSH:
Adult;
Aged;
Anthropometry;
Biological Markers/blood;
Blood Glucose/analysis;
Body Mass Index;
C-Reactive Protein/metabolism;
Female;
Humans;
Insulin/blood;
*Insulin Resistance;
Male;
Metabolic Syndrome X/diagnosis/*metabolism;
Middle Aged;
Obesity/diagnosis/metabolism;
Resistin/*blood;
Subcutaneous Fat/*chemistry;
Tumor Necrosis Factor-alpha/metabolism
- From:Journal of Korean Medical Science
2009;24(4):695-700
- CountryRepublic of Korea
- Language:English
-
Abstract:
The aim of the present study was to investigate the relationship of plasma resistin levels with determinants of the metabolic syndrome (MetS) and anthropometric parameters in healthy Korean subjects. Plasma resistin levels were determined in 276 subjects. In subjects with MetS, the plasma resistin levels were not significantly increased compared to those without MetS (8.3+/-4.3 ng/mL vs. 8.5+/-3.6 ng/mL, respectively, P=0.84). In addition, the plasma resistin levels were not correlated with the body mass index, the waist circumference, homeostasis model assessment-insulin resistance (HOMA-IR), fasting plasma glucose or insulin levels. However, the plasma resistin levels were positively correlated with the abdominal subcutaneous fat (r=0.18, P<0.01) in all subjects and correlated with TNF alpha(r=-0.16, P<0.05) and hsCRP (r=0.15, P<0.05) in subjects without MetS but not with MetS. With multiple linear regression analysis, these linear associations remained to be significant. The results of this study show that plasma resistin levels in humans were not associated with markers of insulin resistance, obesity or other determinants of the MetS.
