A Study on the Effect of Superoxide Dismutase to Sunburn Cell Production in Mouse Skin By Ultraviolet Irradiation.
- Author:
Jin Ho CHUNG
;
Jai Il YOUN
;
Yoo Shin LEE
- Publication Type:Original Article
- Keywords:
Sunburn cell;
Superoxide dismutase;
Ultraviolet lilght
- MeSH:
Animals;
Ear;
Female;
Hair;
Humans;
Mice*;
Skin*;
Sunburn*;
Superoxide Dismutase*;
Superoxides*
- From:Korean Journal of Dermatology
1988;26(5):636-644
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
This study was undertaken to investigate the effect of superoxide dismutase(SOD) to sunburn cell production and development of UV-induced ear swelling reaction in mouse skin after ultraviolet irradiation. In this study, a total of 60 ICR female albino haired mice were used and divided into two groups, A(UVB: 150mJ/cm) and B(UVB:300mJ/cm). Groups of mice were injected intravenouly with SQD(300mJ,/1000cm) just befare UVR and after completion of UVR. The results were as follows . 1. The number of sunburn cells was significantly decreased by injection of SOD (300ug.1000ug)(p<0.05). 2. The number of sunburn cells in a group of mice which was given SOD 1000ug was significantly decreased more than in SOD 300pg(p<0.05). 3. Ear swelling reaction was not significantly suppressed by injection of SOD(300 Pa. 100SC)(p<0 05)
