Comparison of the Effects of Nicorandil and Cocktail Solution to Prevent Radial Artery Spasm during Coronary Angiography.
10.4070/kcj.2006.36.2.133
- Author:
Seong Hwan KIM
1
;
Eung Ju KIM
;
Min Kyu KIM
;
In Sang YUN
;
Woo Jung PARK
;
Sang Jin HAN
;
Goo Yeong CHO
;
Young Jin CHOI
;
Kyung Soon HONG
;
Kyoo Rok HAN
;
Dong Jin OH
;
Chong Yun RHIM
Author Information
1. Division of Cardiology, Department of Internal Medicine, Hallym University Medical Center, Anyang, Korea. ny0021@medimail.co.kr
- Publication Type:Original Article ; Randomized Controlled Trial
- Keywords:
Coronary angiography;
Radial artery;
Spasm;
Nicorandil
- MeSH:
Catheterization;
Catheters;
Constriction, Pathologic;
Coronary Angiography*;
Humans;
Nicorandil*;
Oximetry;
Radial Artery*;
Spasm*;
Vasodilation
- From:Korean Circulation Journal
2006;36(2):133-139
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND AND OBJECTIVES: A radial artery spasm is one of the most common complications of coronary angiography during a transradial, causing considerable patient discomfort, which sometimes disturbs the procedure. This study was designed to evaluate the effects of nicorandil in the prevention of a radial artery spasm during coronary angiography. SUBJECTS AND METHODS: This was a randomized study to compare 4 mg of nicorandil and a 10 mL cocktail solution performed in 100 patients. Vasospasms of the radial artery, which were expressed as stenosis of the vessel diameter with a transradial approach and radial artery patency by pulse oximetry analysis one month later, were examined. RESULTS: Reductions in the systolic and diastolic blood pressures after administration of the spasmolytic agents were 15.8+/-11.8/ 8.4+/-8.0 and 20.5+/-13.6/6.7+/-6.2 in the for nicorandil and cocktail groups, respectively. Nicorandil induced a lesser decrease in the systolic BP than the cocktail, but without statistical significance (p=0.07). Both vasodilating agents showed a significant radial artery vasodilation following their intra-arterial administration (p<0.001 for all). The diameter of the radial artery showed a significant decrease in both groups following catheterization (p<0.05 for all). There were no significant differences between the two groups in terms of radial artery spasms (46 vs. 58% in nicorandil and cocktail groups, respectively, p=0.709). CONCLUSION: Nicorandil, with vasodilatory effects due to a dual mechanism was as effective as the cocktail solution in the vasodilation of the radial artery.
