Expression of E-cadherin in pT2 Lesion of Gastric Cancer.
- Author:
Wha Yeon YANG
1
;
Bon Uk KOO
;
Hyo Yung YUN
;
Dong Hee RYU
;
Young Jin SONG
;
Seok Hyung KIM
;
Sang Yong EOM
;
Heon KIM
Author Information
1. Department of Surgery, College of Medicine, Chungbuk National University, Cheongju, Korea. yunhyo@chungbuk.ac.kr
- Publication Type:Original Article
- Keywords:
E-cadherin;
Gastric adenocarcinoma;
Immunohistochemistry
- MeSH:
Adenocarcinoma;
Animals;
Cadherins*;
Classification;
Gastric Mucosa;
Humans;
Immunohistochemistry;
Lymph Nodes;
Mice;
Neoplasm Metastasis;
Stomach Neoplasms*;
Survival Rate
- From:Journal of the Korean Surgical Society
2006;70(2):91-97
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Abnormal expression of E-cadherin has been shown to play a role in the progression and the metastasis of tumors. We investigated the correlation between the expressions of E-cadherin and the clinicopathologic factors and survival in pT2 gastric adenocarcinomas. METHODS: We examined formalin-fixed, paraffin-embedded archival tissues from 100 surgically resected gastric adeno-carcinomas with pT2 lesion. Tissue preparations were stained with Zymed's monoclonal mouse anti-E-cadherin (clone: 4A2C7). We analyzed the correlation between the expressions of E-cadherin and clinicopathologic factors. RESULTS: Normal gastric mucosa was immunoreactive with anti-E-cadherin antibody. Among the 100 tumors examined, 73 tumors showed expression of E-cadherin. The gender, age, size, depth of invasion, lymph node metastasis, stage (UICC), lymphatic invasion, vascular invasion were not related with E-cadherin expression but Lauren classification and histologic type were strongly correlated with E-cadherin expression (P=0.000, P=0.006). Though patients with dec-rea-sed expression of E-cadherin showed a poorer median survival than normal expression (43.85+/-23.95 months vs. 61.27+/-33.47 months), expression of E-cadherin was not related with survival rate (P=0.668). CONCLUSION: In patients with gastric cancer, expressions of E-cadherin correlated with histologic type and Lauren classi-fication but not with survival.
