Expression of Survivin and HSP90 in Colorectal Cancer and its Relationship with Clinicopathologic Factors.
- Author:
Taeg Hyun KIM
1
;
Tae Jin LEE
;
Beom Gyu KIM
;
Sung Jae CHA
;
Sung Jun PARK
;
Hyun Muck LIM
;
Sung Il PARK
Author Information
1. Department of Surgery, College of Medicine, Chung-Ang University, Seoul, Korea. wuewu@shinbiro.com
- Publication Type:Original Article
- Keywords:
Survivin;
HSP90;
Colorectal cancer
- MeSH:
Apoptosis;
Colorectal Neoplasms*;
Humans;
Immunohistochemistry;
Inhibitor of Apoptosis Proteins;
Neoplasm Metastasis;
Paraffin
- From:Journal of the Korean Surgical Society
2006;70(2):113-119
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Survivin is an inhibitor of apoptosis protein and it is overexpressed in most human cancers. Recent data demonstrated that survivin-HSP90 complex regulate apoptosis. We assessed expression of survivin and HSP90 by using immunohistochemistry with colorectal cancer tissue and correlate it with clinicopathologic prognostic parameters. METHODS: Using immunohistochemistry, survivin and HSP90 expression were evaluated on paraffin sections of fifty-six colorectal carcinomas. Various clinicopathologic parameters including histologic differentiation grade, T-stage, nodal metastasis, stage were obtained from pathologic records. RESULTS: Survivin expression were observed in 30 cases (53.6%). The expression of survivin showed no statistically significant correlation with histologic differentiation grade, T-stage, nodal metastasis, stage. HSP90 expression were observed in 31 cases (55.4%). The expression of HSP90 showed a statistically significant correlation with histologic differentiation grade (P=0.035) and stage (P=0.017). There were a significant correlation between survivin expression and HSP90 expression (P=0.018). CONCLUSION: Survivin and HSP90 was expressed in colorectal cancer. The expression of HSP90 correlates with histologic differentiation grade, stage. The above results suggest that HSP90 could be a prognostic marker of poor outcome in colorectal carcinoma.
