Relationship between excretion of 51Cr-EDTA and mucositis in patients with 5-FU based chemotherapy.
- Author:
Kwon CHOI
1
;
Hyo Sun CHOI
;
Young Choon KIM
;
Jeong Wook KIM
;
Suk Joong OH
;
Woo Kyu JEON
;
Eun Jeong KIM
;
Myong Suk SHIN
;
Seung Sei LEE
Author Information
1. Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea. lss987@samsung.co.kr
- Publication Type:Original Article
- Keywords:
Intestinal permeability;
Chromium-EDTA;
Mucositis;
Chemotherapy
- MeSH:
Drug Therapy*;
Epithelium;
Fluorouracil*;
Healthy Volunteers;
Humans;
Intestines;
Mucositis*;
Mucous Membrane;
National Cancer Institute (U.S.);
Permeability;
Stomatitis
- From:Korean Journal of Medicine
2003;65(6):690-697
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Administration of anticancer drugs may damage gastrointestinal epithelium, thereby increasing the permeability of the gastrointestinal mucosa. It is known that intestinal permeability test using 51Cr-EDTA is a useful test to assess the damage of intestine. The aim of this study was to evaluate intestinal permeability in patients who were treated with 5-fluorouracil (5-FU) based chemotherapy and to evaluate the relationship between the excretion of 51Cr-EDTA and the grading of mucositis. METHODS: Twenty eight patients who were treated with 5-FU based chemotherapy were chosen as study cases while 18 healthy volunteers as controls. Intestinal permeability was assessed by measurement of the urinary excretion of 51Cr-EDTA after oral challenge, and the National Cancer Institute common toxicity criteria were used for assessing oral mucositis. RESULTS: All except 3 patients in the chemotherapy group experienced grade 1~3 stomatitis. The median value of intestinal permeability test was significantly higher in the chemotherapy group than in control group (7.61%, range 2.10-22.92 vs 2.17%, range 1.16-2.76, respectively, p<0.001). The grading of oral mucositis did correlate with the urinary excretion of 51Cr-EDTA (p<0.001, r=0.867). CONCLUSIONS: The measurement of 51Cr-EDTA excretion after oral challenge may be a useful test for evaluating the intestinal permeability by chemotherapy induced intestinal mucosal damage. Testing of intestinal permeability using 51Cr-EDTA may be applicable to evaluate the effect of therapeutic trials in patients with chemotherapy induced mucositis.
