Expression of Transforming Growth Factor-beta Receptors in Food Protein-Induced Enterocolitis Syndrome in Infancy.
- Author:
Hai Lee CHUNG
1
;
Sun Mi CHUNG
;
Gyung Ah HA
;
Jeong Jin LEE
;
Eun Jin CHOI
;
Jin Gyung KIM
;
Woo Taek KIM
;
Un Seok NHO
;
Jin Bok HWANG
;
Jeong Ja PARK
Author Information
1. Department of Pediatrics, The Catholic University of Korea, Taegu, Korea.
- Publication Type:Original Article
- Keywords:
Food Protein-Induced Enterocolitis Syndrome;
TGF-beta receptor
- MeSH:
Atrophy;
Biopsy;
Diarrhea;
Enterocolitis*;
Epithelial Cells;
Humans;
Hypersensitivity;
Infant;
Intestine, Small;
Milk;
Mucous Membrane;
Receptors, Transforming Growth Factor beta;
Transforming Growth Factors;
Vomiting
- From:Pediatric Allergy and Respiratory Disease
2002;12(1):36-43
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Food protein-induced enterocolitis syndrome (FPIES) is a symptom complex of vomiting and diarrhea caused by non-IgE mediated allergy to cow's milk and/or soy in young infants. Transforming growth factor (TGF)-beta has been reported to protect the epithelial barrier of the gut from foreign antigens. We studied the expression of type 1 and 2 TGF-beta receptors in the mucosa of small intestine to investigate their roles in the pathogenesis of FPIES. METHODS: Twenty-eight patients, aged 7 to 120 days (mean 49 days) who were diagnosed with FPIES by clinical criteria and challenge tests were included. Immunohistochemical stainings for type 1 and 2 TGF-beta receptors were performed on endoscopic duodenal biopsy specimens. RESULTS: Type 1 and 2 TGF-beta receptors were expressed in the villous and crypt epithelial cells but nearly absent in the lamina propria in both patients and controls. Type 1 TGF-beta receptor expression was significantly lower in the patients who had villous atrophy than in the patients who had not and in controls. The expression of type 1 TGF-beta receptor was negatively correlated with the severity of villous atrophy. Type 2 TGF-beta receptor expression showed no significant difference between the patients and controls. CONCLUSION: Our results suggests that the decreased activity of type 1 TGF-beta receptor is implicated in the pathogenesis of FPIES in young infants.
