Virus Types and Clinical Patterns in Genital Herpes.
- Author:
Joo Hyung KANG
1
;
Young Suck RO
Author Information
1. Department of Dermatology, Hanyang University College of Medicine, Seoul, Korea. romio@hanyang.ac.kr
- Publication Type:Original Article
- Keywords:
Genital herpes;
Polymerase chain reaction;
Indirect immunofluorescence
- MeSH:
Coinfection;
Fluorescent Antibody Technique, Indirect;
Herpes Genitalis*;
Herpesvirus 1, Human;
Herpesvirus 2, Human;
Humans;
Korea;
Polymerase Chain Reaction;
Recurrence;
Sexually Transmitted Diseases;
Simplexvirus
- From:Korean Journal of Dermatology
2005;43(4):462-468
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Genital herpes is a sexually transmitted disease, which affects millions of people worldwide, and is caused by the herpes simplex virus (HSV). Recent data has shown that in a large proportion of genital herpes, there has been a shift from HSV type 2 (HSV-2) to to HSV type 1 (HS V-1) being the main cause. OBJECTIVE: Our objective was to study the types of virus and clinical patterns of patients with genital herpes in Korea METHODS: We investigated the clinical patterns and virus types of 13 patients with genital herpes using indirect immunofluorescence (IIF) after viral culture, and/or nested-multiplex polymerase chain reaction (NM-PCR). RESULTS: Of the 13 patients, HSV-1 was isolated in 2 patients (15.4%), HSV-2 in 7 patients (53.8%), and mixed infection with both HSV-1 and HSV-2 in 4 patients (30.8%). Recurrence of lesions was found to occur when the patient had HSV-2 or a mixed infection, but not the HSV-1 infection. Of 5 patients who underwent IIF and NM-PCR simultaneously, the virus was detected by NM-PCR only, not by IIF after viral culture, in 2 of the patients. CONCLUSION: HSV-1 infection as a cause of genital herpes is increasing, but recurrence is more common in HSV-2 infection. This study demonstrates that HSV-1 and HSV-2 can be detected simutaneously in the same anatomic region of genital herpes, and that NM-PCR is a more sensitive method for the detection and typing of HSV than IIF after viral culture.
