Comparison of Leukocyte Depletion between COBE Spectra LRSTM and COBE Spectra followed by PALL PXLTM8 on Single Donor Platelet.
- Author:
Suk Im HONG
1
;
Sang Dol KIM
;
Ye Ri Ja PARK
;
Duck Sun LIM
;
Eun Sook JUNG
;
Mee Jung HWANG
;
Ji Hwang LIM
;
Young Gu KIM
;
Jong Wook LEE
;
Kyung Ja HAN
;
Chun Choo KIM
Author Information
1. Apheresis Unit, St. Mary's Hospital, The Catholic University of Korea, Seoul, Korea.
- Publication Type:Original Article ; Randomized Controlled Trial
- Keywords:
Single donor platelet;
COBE Spectra LRS;
PALL filter
- MeSH:
Blood Component Removal;
Blood Group Incompatibility;
Blood Platelets*;
Cytomegalovirus Infections;
Humans;
Leukocytes*;
Prospective Studies;
Tissue Donors*
- From:Korean Journal of Blood Transfusion
1999;10(1):43-51
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Use of single donor apheresis platelets and concerning for the quality of apheresis platelets has been rapidly increased. Apheresis platelets depleted white blood cell (WBC) are used to prevent or to reduce febrile non-hemolytic transfusion reactions, alloimmunization and cytomegalovirus infection. We compared COBE Spectra LRSTM (leukoreduction system) and COBE Spectra with PALL PXLTM8 in terms of the yield predictors, processing times, and WBC contamination. METHOD: Seventy-two single donors who visited Apheresis Unit (APU) in St. Mary's hospital were prospectively randomized into COBE Spectra LRSTM and COBE Spectra followed by PALL PXLTM8 between September 1997 and October 1998. We used Coulter counting for platelet and Nageotte hemocytometer for WBC count. Data were analyzed by independent t-test. RESULTS: The mean platelet yield per unit was 3.6 +/- 1.0X1011 with COBE spectra LRSTM compared to 2.9 +/- 1.1X1011 with COBE Spectra (p=0.002), and the mean WBC content per unit with COBE spectra LRSTM was 4.1X104 (0.4-23.5) compared to 3.7X104 (0.43-17.9) with PALL PXLTM8 (p=0.0728). CONCLUSIONS: This study shows that COBE Spectra LRSTM has higher platelet yields than that of COBE Spectra, and similar WBC contamination compared to PALL PXLTM8. Therefore, this data suggests that COBE Spectra LRSTM is conveient than COBE Spectra with PALL PXLTM8 in clinical practice.
