Induction Chemotherapy Plus Radiation Compared with Surgery Plus Radiation in Patients with Advanced Laryngeal and Hypopharyngeal Cancer.
- Author:
Ki Chang KEUM
1
;
Chang Geol LEE
;
Gwi Eon KIM
;
Kyung Hee LEE
Author Information
1. Department of Radiation Oncology, Yonsei University College of Medicine, Yonsei Cancer Conter, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Induction chemotherapy;
Radiotherapy;
Laryngeal and hypopharyngeal cancer
- MeSH:
Drug Therapy;
Follow-Up Studies;
Humans;
Hypopharyngeal Neoplasms*;
Induction Chemotherapy*;
Laryngectomy;
Larynx;
Neck;
Radiotherapy;
Retrospective Studies;
Survival Rate
- From:Journal of the Korean Society for Therapeutic Radiology
1993;11(2):277-284
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: We performed a retrospective study in patients with previously untreated advanced(Stage III or IV) laryngeal and hypopharyngeal cancer to compare the results of induction chemotherapy followed by definitive radiation therapy (CT+RT) with those of conventional laryngectomy and postoperative radiation therapy (OP+RT). METHOD: Between 1985 and 1990, twenty four patients were treated with two or three courses of chemotherapy and radiation therapy(66~75 Gy). Twenty-five patients were received laryngectomy and radical neck dissection(except 3 patients) and postoperative radiation therapy (55~04 Gy). RESULT: After a median follow-up of 20 months, the actuarial 5-year overall survival rate was 24% (chemotherapy group) and 36% (op group).(P>0.1). The local control rate was the 65%,(13/20) and 68.2%(15/22).(P>0.1). The rate of laryngeal preservation was 65%(13/20) in chemotherapy group. CONCLUSION: Induction chemotherapy and definitive radiation therapy can be effective in preserving the larynx in a high percentage of patients with advanced laryngeal and hypopharyngeal cancer.
