A study on changes of coagulation inhibitors and fibrinolysis inhibitors in patients with liver cirrhosis and hepatoma.
- Author:
Chan Jeoung PARK
1
;
Han Ik CHO
;
Sang In KIM
Author Information
- Publication Type:Original Article
- Keywords: Coagulation and fibrinolysis inhibitors; Liver cirrhosis
- MeSH: Adult; Antifibrinolytic Agents/blood; Blood Coagulation Factors/antagonists & inhibitors/immunology/metabolism; Carcinoma, Hepatocellular/*blood; Hemostasis; Humans; Liver Cirrhosis/*blood; Liver Neoplasms/*blood; Lupus Coagulation Inhibitor
- From:Journal of Korean Medical Science 1991;6(1):1-6
- CountryRepublic of Korea
- Language:English
- Abstract: The authors conducted an investigation focusing mainly on the activities of the inhibitory factors of the coagulation and fibrinolysis processes in 35 normal adults and 72 liver cirrhosis and/or hepatoma patients. The activities of antithrombin III, protein C, and alpha 2-plasmin inhibitor were reduced to less than 50% in patients with decreased hepatic synthetic function while lupus anticoagulant was detected in more than 50% of patients with decreased hepatic synthetic function. Hemostatic abnormalities in advanced lived diseases may be caused partly by a decrease of coagulation and fibrinolysis inhibitors and the presence of lupus anticoagulant.
