A case of gastric hepatoid adenocarcinoma misdiagnosed as an extragonadal germ cell tumor.
- Author:
Seong Hoon JEONG
1
;
Hyun Jeong SHIM
;
Jun Eul HWANG
;
Sang Ho KIM
;
Seong Rye SEO
;
Seong Uk LIM
;
Ik Joo CHUNG
Author Information
1. Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea. ijchung@chonnam.ac.kr
- Publication Type:Case Report
- Keywords:
Gastric cancer;
Alpha-fetoproteins
- MeSH:
Adenocarcinoma*;
Adult;
alpha-Fetoproteins;
Biopsy;
Diagnosis;
Follow-Up Studies;
Gastrectomy;
Germ Cells*;
Humans;
Liver;
Neoplasm Metastasis;
Neoplasms, Germ Cell and Embryonal*;
Prognosis;
Stomach;
Stomach Neoplasms;
Tomography, X-Ray Computed
- From:Korean Journal of Medicine
2007;73(1):107-111
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Hepatoid adenocarcinoma is a rare variant of adenocarcinoma that can occur in the stomach. This neoplasm has a poor prognosis and it frequently presents at an advanced stage of disease; it is clinically characterized by increased serum levels of alpha-fetoprotein (AFP) in most cases. We experienced a case of hepatoid adenocarcinoma of the stomach with multiple liver metastases that mimicked germ cell tumor in a 43-year-old man. He had incidentally detected gastric adenocarcinoma via gastrofibroscopy and he underwent subtotal gastrectomy. The postoperative pathologic stage was II (T2N1M0). He complained of epigastric pain. The serum AFP was markedly increased (227,325 IU/mL) and abdominal CT revealed multiple liver masses. We considered these as extragonadal germ cell tumors that occurred in the liver because of the markedly elevated AFP, the short duration of follow-up and early stage of stomach cancer at the that time. To confirm the diagnosis, biopsy of liver mass was done and he was diagnosed with hepatoid adenocarcinoma.
