Necrotizing lymphadenitis--a clinico-pathologic study of 36 cases with immunohistochemical analysis.
- Author:
Kyung Ja CHO
1
;
Chul Woo KIM
;
Seong Hoe PARK
;
Sang Kook LEE
Author Information
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords: Necrotizing lymphadenitis; Subacute necrotizing lymphadenitis; Immunohistochemistry; S-100 protein; Lysozyme; T cell
- MeSH: Adolescent; Adult; Female; Humans; Immunohistochemistry; Lymphadenitis/etiology/metabolism/*pathology; Male; Muramidase/metabolism; Necrosis; S100 Proteins/metabolism
- From:Journal of Korean Medical Science 1991;6(1):55-61
- CountryRepublic of Korea
- Language:English
- Abstract: Thirty-six cases of necrotizing lymphadenitis--including 33 cases of unknown etiology, 1 typhoid lymphadenopathy, and 2 cases of suspicious lupus lymphadenopathy--were clinico-pathologically reviewed and analyzed with immunostaining for s-100 and lysozyme. All cases histologically showed architectural effacement by paracortical lesions composed of nuclear karyorrhexis and mononuclear cell proliferation. Immunohistochemical study revealed proliferation of lysozyme-positive macrophages in the necrotizing areas and an increase in the number of s-100-positive cells in the uninvolved paracortical areas. This observation suggests that necrotizing lymphadenitis may be a common morphologic expression of a T cell-mediated hyperimmune condition induced by diverse etiologies.
