Carbon monoxide poisoning as an epigenetic factor for Leber's hereditary optic neuropathy.
10.3341/kjo.1996.10.2.122
- Author:
Jeong Min HWANG
1
;
Hye Won PARK
Author Information
1. Department of Ophthalmology, Seoul City Boramae Hospital, Seoul, Korea.
- Publication Type:Case Reports
- Keywords:
carbon monoxide (CO) poisoning;
Leber's hereditary optic neuropathy (LHON)
- MeSH:
Carbon Monoxide/adverse effects;
Carbon Monoxide Poisoning/*complications;
DNA Damage;
DNA, Mitochondrial/genetics;
Female;
Humans;
Middle Aged;
Optic Atrophies, Hereditary/*etiology/genetics;
*Point Mutation;
Visual Acuity
- From:Korean Journal of Ophthalmology
1996;10(2):122-123
- CountryRepublic of Korea
- Language:English
-
Abstract:
A 45-year-old Korean woman visited our hospital complaining of poor vision after carbon monoxide (CO) poisoning. We have confirmed the presence of a point mutation at position 11778 in the ND4 gene of mitochondrial DNA. This case suggests that CO poisoning may precipitate the clinical expression of Leber's hereditary optic neuropathy (LHON). To our knowledge, this would be the first case report of clinical expression of LHON precipitated by CO poisoning.
