Clinical efficacy of various tumor markers in medical screening.
- Author:
Ji Youn KIM
1
;
Seong Chun SHIM
;
Hyun Sik JEONG
;
Seung Sei LEE
Author Information
1. Department of Internal Medicine, Sungkyunkwan University Kangbuk Samsung Hospital, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Tumor markers;
Carcinoembryonic antigen;
Alpha-fetoprotein
- MeSH:
alpha-Fetoproteins;
Carcinoembryonic Antigen;
Carcinoma, Hepatocellular;
Early Diagnosis;
Female;
Humans;
Male;
Mass Screening*;
Pancreas;
Pancrelipase;
Prostatic Neoplasms;
Radioimmunoassay;
Stomach Neoplasms;
Biomarkers, Tumor*
- From:Korean Journal of Medicine
2001;60(2):148-155
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Many tumor markers have been investigated for early diagnosis of the malignancy, yet they were turned out to be inappropriate for the purpose. This study was carried out to investigate the efficacy of tumor markers. METHODS: Employing radioimmunoassay, CEA, AFP, CA19-9, PSA, CA125 were done in 31,389 patients(20,878 males, 10,511 females) who visited our medical screening center from Jan. 1 1997 to Dec. 31 1997. RESULTS: Total mean value of CEA is 1.90+/-1.37 ng/mL(male: 2.17+/-1.37, female: 1.37+/-0.86). Male showed significantly higher level of CEA. Only 2 subjects had values over 25 ng/mL, and one was diagnosed to have stomach cancer but the other did not. Total mean value of AFP is 2.46+/-6.47 ng/mL (male: 2.32+/-3.55 ng/mL, female: 2.73+/-10.06 ng/mL). Female showed significantly higher level of measured AFP. One had AFP value over 400 ng/mL and was diagnosed of hepatoma. Total mean value of CA19-9 is 11.48+/-7.61 ng/mL,(male: 10.9+/-26.78 ng/mL, female: 12.61+/-8.97 ng/mL). Female showed significantly higher CA19-9. 65 subjects (male: 31, female: 34) showed measured CA19-9 level over 37 ng/mL. 5 subjects had values over 100 ng/mL and 1 subject was diagnosed of pancrease cancer. Total mean value of PSA is 0.79+/-1.88 ng/mL. 90 subjects showed measured PSA level over 4 ng/mL and mean value in this group was 10.92 ng/mL. 54 subjects were older than age 50. 4 out of 90 subjects were diagnosed of prostate cancer. Total mean value of CA125 is 13.08+/-10.93 ng/mL. 160 subjects showed measured CA125 level over 35 ng/mL. 19 subjects had value over 100 ng/mL and none of the malignancy was detected. CONCLUSION: Tumor markers are inappropriate measures for screening of malignancy.
