A Prospective Multicenter Study of Community-acquired Pneumonia in Adults with Emphasis on Bacterial Etiology.
- Author:
Jun Hee WOO
1
;
Jae Myung KANG
;
Yang Soo KIM
;
Wan Shik SHIN
;
Jin Hong RYU
;
Jung Hyun CHOI
;
Yang Ree KIM
;
Hee Jin CHEONG
;
Soo Taek UH
;
Choon Sik PARK
;
Moon Hyun CHUNG
;
Kee Suk CHUNG
;
Chan Ju LEE
;
Jiso RYU
Author Information
1. Division of Infectious Diseases, Asan Medical Centre, University of Ulsan, College of Medicine.
- Publication Type:Multicenter Study ; Original Article
- Keywords:
Community-acquired pneumonia (CAP);
Bacterial etiology;
Resistance;
Streptococcus pneumoniae;
Klebsiella pneumoniae;
Pseudomonas aeruginosa
- MeSH:
Adult*;
Animals;
Anti-Bacterial Agents;
Bronchiectasis;
Diagnosis;
Enterobacter cloacae;
Gills;
Gram-Negative Bacteria;
Humans;
Incidence;
Influenza, Human;
Intensive Care Units;
Klebsiella pneumoniae;
Korea;
Lung Diseases, Obstructive;
Male;
Methicillin Resistance;
Mortality;
Penicillins;
Pneumonia*;
Prospective Studies*;
Pseudomonas aeruginosa;
Sputum;
Staphylococcus aureus;
Streptococcus pneumoniae
- From:Korean Journal of Infectious Diseases
2001;33(1):1-7
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Community-acquired pneumonia (CAP) is one of the leading causes of mortality and morbidity. Despite progress in diagnostic techniques and treatments, management of pneumonia remains challenging, because the precise etiology remains uncertain in as many as 49 % of cases. The limitaions of identifying etiologic agents make it necessary to use empiric antibiotics in almost all patients, and furthermore emergence of antibiotic-resistant organisms pose difficulties to the selection of an empiric antibiotic regimen. For the optimal choice of empirical antibiotics, we should know the frequency of etiologic agents and antimicrobial resistance rates in the community. METHODS: A prospective multicenter study of community-acquired pneumonia in Korea was carried out between May 1997 and April 2000. The microbiologic diagnosis was based on the results of sputum culture, blood culture and pleural culture. RESULTS: Five hundred eighty eight cases of community-acquired pneumonia in 562 patients admitted to the hospitals. The mean age was 59.9 with male predominance (58.3%), and 370 (63%) had underlyin gillness. The etiologic agents were identified in 38.3%, and the list of individual agents, in decreasing order, was Streptococcus pneumoniae (21.7%), Klebsiella pneumoniae (14.8%) Pseudomonas aeruginosa (9.8%), Staphylococcus aureus (9.5%), viridans group streptococci (5.7%), Enterobacter cloacae (4.2%), Hemophillus Influenza (3.8%). The rates of admission to the intensive care unit was 10.4%. The motality was 7.1%. Susceptible rates of S. pneumoniae to penicillin was 36.6% and showed multidrug resistant. Forty percents of S. aureus were methicillin-resistant S. aureus. K. penumoniae were susceptible to cephalosporin and quinolone. CONCLUSION: In Korea, S. pneumoniae is the most important agent causing community-acquired pneumonia. Susceptible rates of S. pneumoniae to penicillin was 36.6 % and showed multidrug resistant. Gram negative bacteria such as K. pneumoniae, P. aeruginosa showed high incidence when compared with that of other countries. Most of them had underlying diseases including bronchiectasis and chronic obstructive pulmonary diseases.
