The Expression of Estrogen Receptors in Hepatocellular Carcinoma in Korean Patients.
10.3349/ymj.2006.47.6.811
- Author:
Ai Guo WANG
1
;
Ki Young LEE
;
Seong Yong KIM
;
Jong Young CHOI
;
Kee Ho LEE
;
Wook Hwan KIM
;
Hee Jung WANG
;
Jin Man KIM
;
Moon Gi PARK
;
Young Il YEOM
;
Nam Soon KIM
;
Dae Yeul YU
;
Dong Seok LEE
Author Information
1. KRIBB, Daejeon, Korea. dslee@kangwon.ac.kr
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Androgen receptor;
estrogen receptor-alpha;
receptor-beta;
hepatocellular carcinoma;
hepatitis B virus;
hepatitis C virus
- MeSH:
Sex Factors;
Receptors, Estrogen/*metabolism;
Receptors, Androgen/metabolism;
Middle Aged;
Male;
Liver Neoplasms/ethnology/*metabolism/virology;
Korea;
Humans;
Hepatitis B virus/isolation & purification;
Hepacivirus/isolation & purification;
Female;
Carcinoma, Hepatocellular/ethnology/*metabolism/virology;
Biological Markers/metabolism;
Asian Continental Ancestry Group;
Aged
- From:Yonsei Medical Journal
2006;47(6):811-816
- CountryRepublic of Korea
- Language:English
-
Abstract:
Expression of estrogen receptors (ER)-alpha and -beta, as well as androgen receptor (AR), in hepatocellular carcinoma (HCC) is thought to be correlated with prognosis, survival, and male prevalence of HCC. These hypotheses are based on investigations of European patients; however the expression patterns of these receptors in Asian patients are largely unknown. In this study, we collected liver carcinoma and peritumor tissues from 32 patients (9 females and 23 males) in South Korea. The expression of ERs and ARs was studied using RT-PCR. Wild-type ER-alpha and AR were expressed in all of the samples investigated, and their expression was independent of the causal virus or patient sex. Expression of the ER-alpha variant was independent of sex (100% female vs. 91.3% male) and HCV and HBV status (91.3% vs. 100%). Wild-type ER-beta was expressed more often in HCV patients than in HBV patients (95.7% vs. 44.4%; p < 0.05). In conclusion, the stronger ER-alpha variant expression in HCC tissues implies that this variant has an important role in HCC development. However, at least in Korean patients, expression of the ER-alpha variant (vER-alpha) is not related to male HCC prevalence. In addition, the predominant expression of ER-beta in HCV patients suggests that it plays an important role in HCV-induced liver disease.
