Relationship between Catch-up Growth and Changes in Insulin, Leptin, IGF-I, Adiponectin, and Ghrelin in Infants Born Full-term Small for Gestational Age.
- Author:
Yoon Young YI
1
;
Jung Kyung YOO
;
Hong Kyu PARK
;
Seung YANG
;
Il Tae HWANG
Author Information
1. Department of Pediatrics, College of Medicine, Hallym University, Seoul, Korea. ithwang83@hallym.or.kr
- Publication Type:Original Article
- Keywords:
Infant, small for gestational age;
Growth
- MeSH:
Adiponectin;
Birth Weight;
Female;
Gestational Age;
Ghrelin;
Humans;
Infant;
Infant, Newborn;
Infant, Small for Gestational Age;
Insulin;
Insulin-Like Growth Factor I;
Leptin;
Parturition
- From:Journal of Korean Society of Pediatric Endocrinology
2011;16(2):112-118
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: The aim of the study was to investigate postnatal changes in growth and insulin, leptin, IGF-I, adiponectin, and ghrelin, and to examine the relationship of these hormones with catch-up growth in full-term small for gestational age (SGA) infants. METHODS: SGA was defined as a birth weight less than the ten percentile. Weight and height were measured at birth, 1 month, 6 months, 1 year, and 2 years of age in 70 SGA infants (40 females and 30 males). The infants were subdivided according to their weight and height catch-up growth (CUG) at 2 years old. CUG is defined as reaching a standard deviation score (SDS) of > -2 SDS. Blood samples were serially taken for insulin, leptin, insulinlike growth factor (IGF)-I, adiponectin, and ghrelin. RESULTS: 1) Dramatic CUG for weight and height occurred during the first year of life; weight and height growth gain decreased thereafter. 2) Non-catch-up growth (NCUG) infants showed more decreased weight and height growth gain than CUG infants between the first and second year of life. 3) Weight CUG was 77.1% and height CUG was 75.8% in the SGA infants. 4) Weight CUG infants showed significantly higher leptin and ghrelin levels than in weight NCUG infants at the age of 1 year (P <0.05). 5) Height CUG infants showed significantly higher leptin and ghrelin levels than in height NCUG infants at the age of 1 year (P <0.05). CONCLUSION: CUG for weight and height occurred during the first year of life and growth velocity decreased thereafter. Significant corresponding changes occurred with regard to serum leptin and ghrelin.
