Gender Difference of Accuracy in Detecting Coronary Artery Disease by Myocardial Perfusion SPECT.
- Author:
Ji Yeul KIM
;
Hee Seung BOM
;
Jung Jun MIN
;
Ho Cheon SONG
;
Hwan Jeong JEONG
- Publication Type:Original Article
- Keywords:
99mTc-tetrofosmin;
99mTc-MIBI;
Myocardial SPECT;
Coronary artery disease;
Gender difference;
Soft tissue attenuation
- MeSH:
Arteries;
Artifacts;
Breast;
Constriction, Pathologic;
Coronary Angiography;
Coronary Artery Disease*;
Coronary Vessels*;
Female;
Humans;
Male;
Perfusion*;
Phenobarbital;
Tomography, Emission-Computed, Single-Photon*
- From:Korean Journal of Nuclear Medicine
1998;32(2):129-136
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Myocardial SPECT is an effective test for detecting coronary artery disease in the general population. But the diagnostic accuracy between sexes is not defined. The purpose of this study is to compare the diagnostic accuracy between males and females. MATERIALS AND METHODS: One hundred and seventy seven male and 98 female patients who underwent myocardial SPECT within 1 month of coronary angiography were studied. Myocardial SPECTs were considered abnormal if fixed or reversible perfusion defects were detected. Stenosis severity of > or = 50% luminal diameter reduction of any artery defined coronary artery disease (CAD). RESULTS: Overall sensitivity for detection of CAD was 98% in men and 97% in women (p=not significant). However, specificities, accuracies, and positive predictive values (PPV) in men and women were 49% vs 31% (p<0.05), 81% vs 57% (p<0.01), 78% vs 48% (P<0.01), respectively Diagnostic accuracies for detection of right coronary artery disease were not different in both sexes, however, accuracies for detection of left anterior descending artery disease and left circumflex artery disease were significantly lower in female (p<0.05). CONCLUSION: A significant difference of diagnostic accuracy between sexes, especially in LAD and LCx disease, was noted. Artifacts from breast attenuation might be a cause for the lower diagnostic accuracy in female.
