Down-Regulation of Serum High-Mobility Group Box 1 Protein in Patients with Pulmonary Tuberculosis and Nontuberculous Mycobacterial Lung Disease.
10.4046/trd.2017.80.2.153
- Author:
Su Young KIM
1
;
Won Jung KOH
;
Hye Yun PARK
;
Kyeongman JEON
;
Soo Youn LEE
;
Jae Joon YIM
;
Sung Jae SHIN
Author Information
1. Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
HMGB1 Protein;
Nontuberculous Mycobacteria;
Tuberculosis
- MeSH:
Disease Progression;
Down-Regulation*;
Enzyme-Linked Immunosorbent Assay;
HMGB1 Protein;
Humans;
Lung Diseases*;
Lung*;
Nontuberculous Mycobacteria;
Phenotype;
Tuberculosis;
Tuberculosis, Pulmonary*
- From:Tuberculosis and Respiratory Diseases
2017;80(2):153-158
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Recently, increased levels of high-mobility group box 1 protein (HMGB1) have been identified in various inflammatory conditions and infections. However, no studies have evaluated the HMGB1 level in nontuberculous mycobacterial (NTM) lung disease, and compared it to mycobacterial lung disease. METHODS: A total of 60 patients newly diagnosed with NTM lung disease, 44 culture-positive pulmonary tuberculosis (TB) patients, and 34 healthy controls, were included in this study. The serum HMGB1 concentrations were quantified using HMGB1 enzyme-linked immunosorbent assay kits. RESULTS: Serum HMGB1 level in patients with pulmonary TB or NTM lung disease, was significantly lower than that of the healthy controls. In addition, the serum HMGB1 level in TB patients was significantly lower than patients with NTM lung disease. However, the levels in NTM patient subgroups did not differ according to the causative species, disease progression, and disease phenotype. CONCLUSION: Although low levels of serum HMGB1 has the potential to be a marker of mycobacterial lung disease, these levels were unable to differentiate disease progression and disease phenotype in NTM lung diseases.
