Percutaneous Cryoablation for the Normal Lung evaluated in Rabbits: A Radiologic-Pathologic Correlation.
10.3348/jkrs.2008.58.3.255
- Author:
Young Jun KIM
1
;
Gong Yong JIN
;
Young Min HAN
;
Gyung Ho CHUNG
;
Eun Jeoung CHOI
;
Myung Ja CHUNG
Author Information
1. Department of Diagnostic Radiology, Chonbuk National University Hospital, Korea. gyjin@chonbuk.ac.kr
- Publication Type:Original Article
- Keywords:
Catheter ablation;
Cryotherapy;
Rabbits;
Lung neoplasms
- MeSH:
Animals;
Catheter Ablation;
Cryosurgery;
Cryotherapy;
Freezing;
Lung;
Lung Neoplasms;
Necrosis;
Rabbits;
Thorax
- From:Journal of the Korean Radiological Society
2008;58(3):255-260
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To assess the CT and histological findings after cryoablation in the normal lung of rabbits. MATERIALS AND METHODS: After performing chest CT on rabbits, we inserted a cryoneedle toward the lower lobe of the right lung. We performed percutaneous cryoablation that was composed of freeze-thaw-freeze cycles (25 minutes) for group 1 animals and one cycle of variable freezing time (10-20 minutes) for group 2 animals. We measured the longest (Dl) and shortest diameter (Ds) of the ablated zones that were determined after cryoablation for all of the CT images. After cryoablation, we performed a pathological examination. RESULTS: The mean Dl and Ds of the ablated zone was 28.1+/-3.9 mm and 16+/-1.6 mm, respectively, for group 1 rabbits. For group 2 rabbits, the mean Dl and Ds was 28.7+/-6.3 mm and 14.4+/-3.8 mm, respectively, for one cycle of 20 minutes freezing time. Based on the histological findings, the ablated zone was composed of a necrotic, hemorrhagic, and inflammatory area, in order from the center to the outside. Although each area was well differentiated in group 1 rabbits, only freezing for one cycle of 20 minutes for the group 2 rabbits gave the same results as for the group 1 rabbits. CONCLUSION: A total freezing time of at least 20 minutes and two more freeze-thaw-freeze cycles might be important factors for providing a sufficient area of the ablated zone and uniform necrosis during cryoablation.
