Thermolabile Methylenetetrahydrofolate Reductase Gene Variants in Korean Women with Severe Preeclampsia.
- Author:
Ill Woon JI
1
;
Eun Hwan JEONG
;
Hak Soon KIM
;
Yong Beom KIM
;
Jae Sook RHO
;
Seung Hwa HONG
;
Jeong Kyu KIM
;
Myeong Chan CHO
Author Information
1. Department of Obstetrics and Gynecology, Chungbuk National University College of Medicine, Cheungju, Korea.
- Publication Type:Original Article
- Keywords:
Preeclampsia;
Methylenetetrahydrofolate reductase;
Polymorphism
- MeSH:
Alleles;
Female;
Gene Frequency;
Genotype;
Humans;
Methylenetetrahydrofolate Reductase (NADPH2)*;
Oxidoreductases;
Polymerase Chain Reaction;
Pre-Eclampsia*;
Pregnancy;
Restriction Mapping
- From:Korean Journal of Obstetrics and Gynecology
2001;44(11):2104-2108
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: This study was performed to evaluate C to T substitution at nucleotide 677 of meth-ylenetetrahydrofolate reductase gene in Korean women, which is genetically homogeneous, with preeclamptic or normotensive pregnancies. METHODS: Methylenetetrahydrofolate reductase genotypes were determined in 63 Korean women with severe preeclamptic pregnancies and 60 controls with normotensive pregnancies, using polymerase chain reaction and restriction enzyme analysis. RESULTS: The methylentetrahydrofolate reductase genotype and allele frequencies in preeclamptic and control women did not differ significantly. The frequency of the T677 allele was 38.1% in the preeclamptic group and 41.7% in the control group, and TT homozygosity was found in 12 preeclamptic women (19.0%) and 10 controls (16.7%). CONCLUSION: It seems like that there is no evidence of association of preeclampsia with meth-ylenetetrahydrofolate reductase gene polymorphism, at least in the Korean population.
