The Effect of Vitreous on Proliferation of Retinal Pigment Epithelial CelIs.
- Author:
Sung Chul LEE
1
;
Oh Woong KWON
Author Information
1. Department of Ophthalmology, Yonsei University, College of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
RPE cells;
Cell proliferation;
Vitreous;
Proliferative vitreoretinopathy
- MeSH:
Cell Proliferation;
Membranes;
Retinaldehyde*;
Vitreoretinopathy, Proliferative
- From:Journal of the Korean Ophthalmological Society
1993;34(4):299-303
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Several studies have indicated that retinal pigment epithelial(RPE) cells migrate from their normal location into the vitreous cavity where they then undergo proliferation and membrane formation in proliferative vitreoretinopathy(PVR). Little attention has been given to the role of vitreous on cellular proliferation. Our study is to determine the effect of vitreous on RPE cell proliferation and to examine the morphology of cultured RPE cells on vitreous explants. The vitreous from pigmented rabbit was extracted and added to the cultured media RPE cells proliferated rapidly along the margin of the vitreous as fibrocyte like cells and were less invasive into the virtrous gel. Liquified vitreous with media stimulated the proliferation of RPE cells, but vitreous alone showed the decrease of inoculated RPE cells.
