Protective Effect of Arabinoxylan against Scopolamine-Induced Learning and Memory Impairment.
10.4062/biomolther.2014.063
- Author:
Chang Yul KIM
1
;
Gil Yong LEE
;
Gyu Hwan PARK
;
Jongwon LEE
;
Jung Hee JANG
Author Information
1. Department of Pathology, College of Oriental Medicine, Daegu Haany University, Daegu 706-828, Republic of Korea.
- Publication Type:Original Article
- Keywords:
Arabinoxylan;
Brain-derived neurotrophic factor;
cAMP response element binding protein;
Learning and memory;
Scopolamine
- MeSH:
Administration, Oral;
Amnesia;
Animals;
Brain-Derived Neurotrophic Factor;
Cyclic AMP Response Element-Binding Protein;
Dietary Fiber;
Learning*;
Maze Learning;
Memory*;
Rats;
Rats, Sprague-Dawley;
Scopolamine Hydrobromide;
Triticum;
Up-Regulation
- From:Biomolecules & Therapeutics
2014;22(5):467-473
- CountryRepublic of Korea
- Language:English
-
Abstract:
The purpose of this study is to investigate the memory enhancing effect and underlying molecular mechanism of arabinoxylan (AX), a major component of dietary fiber in wheat against scopolamine (SCO)-induced amnesia in Sprague-Dawley (SD) rats. Diverse behavior tests including Y-maze, Morris water maze, and passive avoidance tests were performed to measure cognitive functions. SCO significantly decreased the spontaneous alterations in Y-maze test and step-through latency in passive avoidance test, whereas increased time spent to find the hidden platform in Morris water maze test compared with the sham control group. In contrast, oral administration of AX (25 mg/kg and 50 mg/kg) effectively reversed the SCO-induced cognitive impairments in SD rats. Furthermore, AX treatment up-regulated the expression of brain-derived neurotrophic factor (BDNF) in the cortex and hippo-campus via promoting activation of cAMP response element binding protein (CREB). Therefore, our findings suggest that AX can improve SCO-induced learning and memory impairment possibly through activation of CREB and up-regulation of BDNF levels, thereby exhibiting a cognition-enhancing potential.
