Analysis of Single Nucleotide Polymorphisms of COMT Gene in Korean Schizophrenics.
- Author:
Dong Ki LEE
1
;
Seong Hwan KIM
;
Byeong Moo CHOE
;
Jae Hong PARK
;
Seung Rak SON
;
Ho Jin KANG
;
Young Seoub HONG
Author Information
1. Department of Psychiatry, College of Medicine, Dong-A University, Busan, Korea. shkim@dau.ac.kr
- Publication Type:Original Article
- Keywords:
Schizophrenia;
SNPs;
COMT gene;
Allele;
Genotype;
Haplotype;
Association study
- MeSH:
Age of Onset;
Alleles;
Catechol O-Methyltransferase;
Catecholamines;
Dopamine;
Female;
Gene Frequency;
Genotype;
Haplotypes;
Humans;
Polymorphism, Single Nucleotide;
Schizophrenia
- From:Journal of Korean Neuropsychiatric Association
2010;49(2):201-209
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVES: Catechol-O-methyltransferase (COMT) plays an important role in metabolizing catecholamines, including dopamine. Also, several single-nucleotide polymorphisms (SNPs) of the COMT gene are associated with schizophrenia. Therefore, this study aimed to find the association between COMT gene SNPs and schizophrenia in Koreans. METHODS: Participants were 366 schizophrenia patients and 359 normal controls. To identify the SNPs, we performed genetic analyses in 4 SNP regions, via SNP-ITTM assays. We compared allele, genotype, and haplotype frequencies between the two groups. Moreover, we built subgroups, based on onset age, and compared individual allele and genotype frequencies among these subgroups. RESULTS: In female patients, genotype frequencies showed a significant difference in rs2020917 among the 4 SNPs (p=0.0224), but haplotype frequencies showed no such difference among the 4 SNPs between patients and controls. We noted a significant difference in rs1544325 allele frequencies according to onset age. Also, in female patients, rs1544325 allele and genotype frequencies varied significantly according to onset age. CONCLUSION: This study found no genetic association between the COMT gene's 4 SNPs and schizophrenia in Koreans. However, our findings suggest genetic components for sex-specificity and onset age in Korean schizophrenics.
