Neoadjuvant human epidermal growth factor receptor-2 targeted therapy in patients with locally advanced breast cancer.
10.4174/jkss.2013.84.5.273
- Author:
Dong Hui CHO
1
;
Se Kyung LEE
;
Sangmin KIM
;
Min Young CHOI
;
Seung Pil JUNG
;
Jeonghui LEE
;
Jiyoung KIM
;
Min Young KOO
;
Soo Youn BAE
;
Jung Han KIM
;
Jee Soo KIM
;
Kil Won HO
;
Jeong Eon LEE
;
Seok Jin NAM
;
Jung Hyun YANG
Author Information
1. Department of Surgery, Seoul Medical Center, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Breast neoplasms;
Neoadjuvant therapy;
ErbB-2;
Response
- MeSH:
Breast;
Breast Neoplasms;
Epidermal Growth Factor;
Humans;
Mastectomy, Segmental;
Neoadjuvant Therapy;
Polymerase Chain Reaction;
Retrospective Studies
- From:Journal of the Korean Surgical Society
2013;84(5):273-280
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: We analyzed the responses of patients with locally advanced breast cancer to neoadjuvant chemotherapy (NAC) and NAC combined with neoadjuvant human epidermal growth factor receptor-2 (HER2) targeted therapy (NCHTT). METHODS: We retrospectively reviewed 59 patients with HER2 amplified locally advanced breast cancer among patients who were treated surgically after neoadjuvant therapy at Samsung Medical Center between 2005 and 2009. Thirty-one patients received conventional NAC and 28 patients received NCHTT. Pathologic responses were assessed according to response evaluation criteria in solid tumors (RECIST) guidelines. RESULTS: Pathologic complete response (pCR) was achieved in 13 out of 28 patients treated with NCHTT and in 6 out of 31 patients treated with NAC alone (46.4% vs. 19.4%, respectively, P = 0.049). Breast conserving surgery (BCS) was more frequently performed in the NCHTT group than in the NAC only group (71.4% vs. 19.4%, P < 0.001). The 3-year recurrence-free survival (RFS) rate was 100% in the NCHTT group and 76.4% in the NAC group (P = 0.014). Together, NCHTT, type of operation (BCS vs. mastectomy) and pathologic nodal status were significant prognostic factors for RFS in univariate analysis. CONCLUSION: We found that NCHTT produced higher pCR rates than NAC alone in locally advanced breast cancer.
