A Case of AA Amyloidosis Treated with Infliximab.
- Author:
Da Ham KIM
1
;
Kyeong Hye PARK
;
Su Hwan LEE
;
Shin Young HYUN
;
Jeong Hae KIE
;
Ea Wha KANG
Author Information
1. Department of Internal Medicine, National Health Insurance Corporation Ilsan Hospital, Goyang, Korea. eawha@medimail.co.kr
- Publication Type:Case Report
- Keywords:
Amyloidosis;
Rheumatoid arthritis;
Infliximab
- MeSH:
Amyloid;
Amyloidosis;
Antibodies, Monoclonal;
Arthritis, Rheumatoid;
Biopsy;
Birefringence;
Female;
Humans;
Inflammation;
Necrosis;
Infliximab
- From:Korean Journal of Nephrology
2010;29(5):638-643
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
AA amyloidosis is one of the most significant complications of rheumatoid arthritis characterized by the deposition of amyloid A (AA) in multiple organs and tissues in the body. This disorder displays variable clinical symptoms depending upon the involved organ and a diagnosis is rendered through a biopsy of the affected organ, followed by staining using Congo-red which reveals an apple-green birefringence. Fundamental disease control is critical in the treatment of AA amyloidosis. Anti-tumor necrosis factor alpha (anti TNF-alpha) agents are promising in inducing clinical remission by suppressing systemic inflammation in AA amyloidosis. We report a case of AA amyloidosis in a 71 year old woman with rheumatoid arthritis that responded well to infliximab therapy.
