Type III hyperlipoproteinemia associated with generalized tuberoeruptive xanthomas.
- Author:
Hyun LIM
1
;
Dal Sik KIM
Author Information
1. Department of Clinical Pathology, Chonbuk National University Medical School, Chonju, Korea.
- Publication Type:Original Article
- Keywords:
Type III hyperlipoproteinemia;
Apolipoprotein E;
apo 2/2;
Xanthoma
- MeSH:
Apolipoprotein E2;
Cholesterol;
Citrus sinensis;
Coronary Artery Disease;
Diet;
Electrophoresis;
Female;
Humans;
Hypercholesterolemia;
Hyperlipoproteinemia Type III*;
Hypertriglyceridemia;
Lipoproteins;
Middle Aged;
Plasma;
Triglycerides;
Xanthomatosis*
- From:Korean Journal of Clinical Pathology
2001;21(4):269-273
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
A 61-year-old female patient presented with the type III hyperlipoproteinemia (HLP) in association with generalized eruptive and tuberous xanthomas. She had hypercholesterolemia and hypertriglyceridemia, and extensive coronary atherosclerosis. Further studies revealed a positive standing plasma test, abnormal beta-very low density lipoprotein (VLDL) on lipoprotein electrophoresis, markedly elevated very low density lipoprotein-cholesterol (VLDL-C) to plasma triglycerides (TG) ratio (0.86) and homozygosity for apolipoprotein E2. After about one year of therapy with lipid-lowering agents and diet restriction, a significant reduction of serum cholesterol and TG was observed and the yellowish orange discolorations of palmar creases disappeared from her palms.
