Patient's Perception of Symptoms Related to Morning Activity in Chronic Obstructive Pulmonary Disease: The SYMBOL Study.
10.3904/kjim.2012.27.4.426
- Author:
Yeon Jae KIM
1
;
Byung Ki LEE
;
Chi Young JUNG
;
Young June JEON
;
Dae Sung HYUN
;
Kyung Chan KIM
;
Sung Ken YU
;
Hye Sook CHOI
;
Won Hyuk SHIN
;
Kwan Ho LEE
Author Information
1. Division of Pulmonary and Critical Care Medicine, Daegu Fatima Hospital, Daegu, Korea.
- Publication Type:Original Article ; Multicenter Study ; Observational Study ; Research Support, Non-U.S. Gov't
- Keywords:
Perception;
Morning;
Symptoms;
Activities;
Chronic obstructive pulmonary disease
- MeSH:
Activities of Daily Living;
Aged;
Circadian Rhythm;
Female;
Forced Expiratory Volume;
Humans;
Male;
Middle Aged;
Perception;
Prospective Studies;
Pulmonary Disease, Chronic Obstructive/drug therapy/*physiopathology;
Questionnaires
- From:The Korean Journal of Internal Medicine
2012;27(4):426-435
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND/AIMS: Patients with chronic obstructive pulmonary disease (COPD) experience more problematic respiratory symptoms and have more trouble performing daily activities in the morning. The aim of this study was to assess the perception of COPD symptoms related to morning activities in patients with severe airflow limitation. METHODS: Data of 133 patients with severe airflow limitation were analyzed in a prospective, non-interventional study. A clinical symptom questionnaire was completed by patients at baseline. In patients having morning symptoms, defined by at least one or more prominent or aggravating symptom during morning activities, a morning activity questionnaire was also completed at baseline and following 2 months of COPD treatment. RESULTS: The most frequently reported COPD symptom was breathlessness (90.8%). Morning symptoms were reported in 76 (57%) patients; these had more frequent and severe clinical COPD symptoms. The most frequently reported morning activity was getting out of bed (82.9%). The long acting muscarinic antagonist (odds ratio [OR], 6.971; 95% confidence interval [CI], 1.317 to 11.905) and chest tightness (OR, 0.075; 95% CI, 0.011 to 0.518) were identified as significantly related to absence of morning symptoms. There was no significant correlation between the degree of forced expiratory volume in 1 second improvement and severity score differences of all items of morning activity after 2-month treatment. CONCLUSIONS: Fifty-seven percent of COPD patients with severe airflow limitation have morning symptoms that limit their morning activities. These patients also have more prevalent and severe COPD symptoms. The results of this study therefore provide valuable information for the development of patient-reported outcomes in COPD.
