The Effect of Carbon Monoxide Intoxication on The Metabolites of Monoamine Neurotransmitters in Human Cerbrospinal Fluid.
- Author:
Dong Kwon KIM
1
;
Hong Ki SONG
;
Ju Han KIM
;
Kyung Cheon CHUNG
;
Yong Sung LEE
Author Information
1. Department of Neurology, College of Medicine, Hanyang University, Korea.
- Publication Type:Original Article
- MeSH:
Acetic Acid;
Anoxia;
Carbon Monoxide*;
Carbon*;
Cerebrospinal Fluid;
Chromatography, Liquid;
Homovanillic Acid;
Humans*;
Hydroxyindoleacetic Acid;
Metabolism;
Monoamine Oxidase;
Neurotransmitter Agents*
- From:Journal of the Korean Neurological Association
1990;8(2):249-255
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
This study was done in order to show the effects of carbon rnonoxide (CO) induced hypoxia on the steps of metabolism of rnonoamine neurotransmitters. There were 9 patients exposed to CO and 5 patients of control group. We evaluated their cerebrospinal fluid within 24 hours after CO exposure. And we measured the amounts of 5-hydroxy-indole acetic acid (5-HIAA) and homovanillic acid (HVA) with high performance liquid chromatography (HPLC). In the CO exposure group, the levels of 5-HIAA and HVA were reduced compared with the control group. It was thought that the changes in the levels of 5-HIAA and HVA were due to the transient decrease in monoamine oxidase activity in acute hypoxia.
