Apoptotic Keratinocytes in Acrodermatitis Enteropathica.
- Author:
Young Lip PARK
1
;
Kyu Uang WHANG
;
Sung Won BANG
;
Young Keun KIM
;
Hee Joon YU
;
Sook Ja SON
Author Information
1. Department of Dermatology, Soonchunhyang University College of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Apoptosis;
TUNEL;
Zinc deficiency
- MeSH:
Acrodermatitis*;
Apoptosis;
Biopsy;
Biotin;
Epidermis;
Epithelium;
In Situ Nick-End Labeling;
Keratinocytes*;
Myeloid Cells;
Skin;
Transferases;
Zinc
- From:Korean Journal of Dermatology
1996;34(5):753-756
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: The cause of acrodermatitis enteropathica(AE) is closely related to zinc deficiency. Zinc is a potent inhibitor of endonuclease. Acute rises in the apoptosis in lymphoid and myeloid cell lines during zinc deficiency has recently been reported. The method of terminal transferase mediated dUTP biotin nick end labeling(TUNEL) is used in situ labelling of apoptotic nuclei in routine tissue sections. OBJECTIVE: The purpose of this study is to clarify our hypothesis that apoptosis resulted from zinc deficiency might cause keratinocytes damages in AE. METHOD: We stained 6 AE biopsy specimen with TUNEL technique. RESULTS: In acroderrratitis enteropathica, apoptotic keratinocytes were shown in the entire epidermis as compared to normal, controlled skin, in which it was found only at the uppermost layer of this stratified epithelium. CONCLUSION: This result suggests that apoptosis resulting from zinc deficiency might play a role in keratinocyte death in AE.
