A Case Report of t(8;22) with Additional Chromosomal Defects in Bone Marrow Involvement of B Cell Type Diffuse Large Cell Lymphoma.
- Author:
Kwang Hee LEE
1
;
Young Kyung LEE
;
Ji Young PARK
;
Hyun Bae JEON
;
Jin Seok AHN
;
Jung Ae LEE
;
Young Suk PARK
;
Hyoun Chan CHO
Author Information
1. Department of Clinical Pathology, Hallym University College of Medicine, Seoul, Korea.
- Publication Type:Case Report
- Keywords:
t(8;
22);
Diffuse large cell lymphoma;
Chromosome study
- MeSH:
Abdominal Pain;
Bone Marrow*;
Burkitt Lymphoma;
Chromosome Aberrations;
Colon, Sigmoid;
Drug Therapy;
Humans;
Immunoglobulins;
Karyotype;
Korea;
Lymphoma;
Lymphoma, Large B-Cell, Diffuse*;
Male;
Membranes;
Metaphase;
Middle Aged;
Radiotherapy
- From:Korean Journal of Clinical Pathology
1998;18(4):525-528
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The t(8;14)(q24;q32) translocation or its variants, t(2;8)(p12;q24) and t(8;22)(q24;q32) are classically seen in Burkitt's lymphoma, but are also found in diffuse large cell lymphoma (DLCL). Burkitt's lymphoma is very rare in Korea and t(8;14) or its variants have not been reported. We report a case of DLCL (B-cell type) with t(8;22) and additional chromosomal abnormalities. The patient, 45-year-old male, complained intermittent abdominal pain. The histologic examination of sigmoid colon revealed DLCL. Lymphoma cells were counted about 58.8% of all nucleated cells in bone marrow aspiration and showed surface membrane immunoglobulin positivity. Chromosome study of bone marrow aspiration was done using high resolution banding technique. The karyotype was 47,XY,+1,del(6)(q21),t(8;22)(q24;q11),del(13)(q31),der(14)t(1;14)(q23;q32)?, del(17)(p11) in all of the nineteen metaphases which were analyzed. Although he was treated by chemotherapy and radiotherapy, lymphoma cells were increased in peripheral blood and he expired.
