A Experimental Study for the Effect of Sodium Carboxymethyl Cellulose on Prevention of Percardial Adhesion.
- Author:
Seock Yeol LEE
1
;
Cheol Woo JEON
;
Man Bok LEE
;
Kihl Rho LEE
;
Eun Suk KOH
;
Young Ik UHM
Author Information
1. Department of Thoracic & Cardiovascular Surgery, Soonchunhyang University Kumi Hospital, Soonchunhyang University College of Medicine, Korea.
- Publication Type:Original Article
- Keywords:
Pericardium;
Adhesion;
Models, experiment
- MeSH:
Carboxymethylcellulose Sodium*;
Cellulose;
Incidence;
Models, Animal;
Pericardium;
Rabbits;
Sodium*;
Thoracic Surgery
- From:The Korean Journal of Thoracic and Cardiovascular Surgery
2000;33(7):541-546
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Pericardial adhesion poses a major problem during re-operative cardiac surgery. The purpose of this study was to determine the effect of sodium carboxymethol cellulose on experimental pericardial adhesions. MATERIAL AND METHOD: Twenty-four rabbits were divided into 2 groups of 12 rabbits each and pericardial mesothelial injury was induced by abrasion. Group A included rabbits receiving intrapericardial injection of Ringer's solution, and Group B included rabbits receiving intrapericardial injection of 3% sodium carboxymethoyl cellulose solution. Three weeks after the surgery, the incidence of adhesions in Group A was compared with that in Group B. RESULT: Pericardial adhesions were evaluated by tenacity and type scores. Tenacity scores of 3 or greater were considered clinically significant adhesion. Pericardial adhesion was found in 100% of rabbits in group A. However 25% of the rabbits in Group B had pericardial adhesions(p<0.0001). Type scores were also considered clinically significant between 2 groups. CONCLUSION: Our findings demonstrated that intrapericardial injection of 3% sodium carboxymethyl cellulose solution reduced the incidence of pericardial adhesions in an animal models.
