Multiple Organ Dysfunction Syndrome.
10.5124/jkma.2002.45.2.198
- Author:
Young Gwan KO
- Publication Type:Original Article
- Keywords:
Inflammatory response;
Multiple organ dysfunction syndrome
- MeSH:
Blood Transfusion;
Cause of Death;
Chemotaxis;
Epidemiology;
Humans;
Immunosuppression;
Inflammation;
Intensive Care Units;
Multiple Organ Failure*;
Neutrophils;
Nutritional Support;
Oxygen;
Oxygen Consumption;
Xanthine
- From:Journal of the Korean Medical Association
2002;45(2):198-205
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Multiple organ dysfunction syndrome(MODS) emerged as a new syndrome about 30 years ago as a result of the ability to keep patients alive with advanced medical technology. Despite intensive investigation, it remains the main cause of deaths in the intensive care unit today. MODS was presumed to be caused by various pathophysiologic conditions. The epidemiology and pathophysiology include infectious mode 1 and 2, 1-hit and 2-hit models, dysfunctional inflammatory response, impaired oxygen consumption, xanthine oxidase-dependent reactive oxygen metabolites, neutrophil chemotaxis, polymorphonuclear neutrophil adherence, gut hypothesis, and immunosuppression from blood transfusion. Unfortunately, once MODS develops, our current understanding of the inflammatory response is inadequate to manage the condition. Our only recourse is to control the source of inflammation, support the failing organs, provide nutritional support, and prevent further iatrogenic injury.
