The Effects of Aprotinin on ACT and the Total Amount of Heparin for Open Heart Surgery.
- Author:
Hyun Woo LEE
;
Jae Woong LEE
;
Chul Hyun PARK
;
Kook Yang PARK
- Publication Type:Original Article
- MeSH:
Aprotinin*;
Body Height;
Body Weight;
Cardiopulmonary Bypass;
Constriction;
Heart*;
Heparin*;
Humans;
Schools, Medical;
Serine Proteases;
Thoracic Surgery*
- From:The Korean Journal of Thoracic and Cardiovascular Surgery
2000;33(7):560-564
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Aprotinin, which is a nonspecific serine protease inhibitor, has an antiinflammatory and thrombogenic effect. However, it has an antithrombogenic effect during the cardiopulmonary bypass. This study was performed to evaluated the effects of aprotinin on the activated clotting time(ACT) and the total amount of the heparin used during the cardiopulmonary bypass. MATERIAL AND METHOD: From December 1998 to November 1999, 82 consecutive patients electively underwent open heart surgery at Gachon medical school. The patients were older than 18 years. Eighty two patients were classified into a control group(group C, n=36) and a aprotinin-treated group(group A, n=46). Body weight, height, body surface area(BSA), pump time(PT), aortic cross clamping time(ACCT), and body temperature(BT) were determined. Total amount of heparin and protamine during the CPB were also measured. ACT was determined before heparin administration, at 20, 40 and 60 minutes after heparin administration, and after protamine administration. RESULT: No significant differences were noted in either group in body weight, height, BSA, BT, and the total amoun of heparin and protamine. Group A demonstrated a significant(p<0.05) increase in age, PT, ACCT, and ACT at 20, 40, and 60 minutes after heparin administration. CONCLUSION: In summary, the use of aprotinin prime resulted in an increase in ACT. The total amount of heparin in aproinin-treated patient was similar to that of the control group in spite of having the prolonged pump time. Therefore aprotinin may reduce the requirement of heparin.
