Ondine's Curse Consequent to Recurrent Respiratory Failure in a Man with Leber Hereditary Optic Neuropathy.
- Author:
Sangwon HA
1
;
Seong Gi AN
;
Sang Ahm LEE
Author Information
1. Department of Neurology, University of Ulsan College of Medicine, Seoul, Korea. salee@www.amc.seoul.kr
- Publication Type:Case Report
- Keywords:
Leber's hereditary optic neuropathy;
Recurrent respiratory failure;
Medulla oblongata
- MeSH:
Brain;
DNA, Mitochondrial;
Humans;
Magnetic Resonance Imaging;
Medulla Oblongata;
Mesencephalon;
Mitochondrial Diseases;
Optic Atrophy, Hereditary, Leber*;
Pons;
Respiratory Center;
Respiratory Insufficiency*
- From:Journal of the Korean Neurological Association
2004;22(4):414-417
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Leber's hereditary optic neuropathy (LHON) is a disease due to mitochondrial DNA mutations. We report a man with LHON, who presented with four episodes of respiratory failure. In the last episode, he had a loss of the automatic component of the respiratory drive but retained the voluntary component. Brain MRI showed lesions in the midbrain, pons, and medulla oblongata, involving the neuroanatomic areas of the medullary respiratory center. Our patient provides a further example of the broad manifestations of mitochondrial disease.
