Evidence-Based Korean Pharmacological Treatment Guideline for Depression, Revised Edition (II) : Antidepressant Efficacy Compared with Placebo, Difference in Efficacy of Antidepressants, and Appropriate Time of Efficacy Judgment in Antidepressant Therapy.
10.4306/jknpa.2013.52.5.372
- Author:
Seung Hwan SUNG
1
;
Seon Cheol PARK
;
Kyu Man HAN
;
Eun Soo WON
;
Hwa Young LEE
;
Jae Woo KOO
;
Jong Woo PAIK
;
Kyung Min LEE
;
Hong Jin JEON
;
Moon Soo LEE
;
Se Hoon SHIM
;
Young Hoon KO
;
Kang Joon LEE
;
Changsu HAN
;
Byung Joo HAM
;
Joonho CHOI
;
Tae Yeon HWANG
;
Kang Seob OH
;
Yong Chon PARK
;
Min Soo LEE
;
Sang Woo HAHN
Author Information
1. Department of Psychiatry, College of Medicine, Soonchunhyang University, Cheonan, Korea.
- Publication Type:Original Article
- Keywords:
Major depressive disorder;
Guideline;
Antidepressant;
Placebo;
Difference in efficacy;
Appropriate time;
Efficacy judgment
- MeSH:
Antidepressive Agents*;
Antidepressive Agents, Tricyclic;
Depression*;
Depressive Disorder, Major;
Dopamine Uptake Inhibitors;
Judgment*;
Monoamine Oxidase Inhibitors;
Norepinephrine;
Peer Review;
Serotonin;
Serotonin Uptake Inhibitors
- From:Journal of Korean Neuropsychiatric Association
2013;52(5):372-385
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVES: The purpose of this study was to suggest recommendations of antidepressant efficacy compared with placebo, difference in efficacy of antidepressants, and appropriate time of efficacy judgment in antidepressant therapy. METHODS: Using recommendations from 12 international and domestic clinical practice guidelines for depression, drawing of recommendation drafts, and peer review, the executive committee developed the guideline. RESULTS: Tricyclic antidepressants (TCAs), monoamine oxidase inhibitors (MAOI), selective serotonin reuptake inhibitors (SSRI), serotonin and norepinephrine reuptake inhibitors (SNRIs), norepinephrine and specific serotonergic antidepressants (NaSSAs), norepinephrine and dopamine reuptake inhibitors (NDRIs), and serotonin antagonist and reuptake inhibitors (SARIs) were strongly recommended as having antidepressant efficacy compared with placebo. Difference in efficacy of antidepressants was as follows. TCAs, MAOI, SSRI, SNRIs, and NaSSAs were strongly recommended, however, NDRIs, SARIs were weakly recommended. If there was no or minimal improvement with treatment, appropriate time of efficacy judgment in antidepressant therapy was estimated to be after two to four weeks. CONCLUSION: We hope that the results of this study will be helpful in encouraging the optimal treatment by understanding antidepressant efficacy compared with placebo, difference in efficacy of antidepressants, and appropriate time of efficacy judgment in antidepressant therapy.
