Caspase-1 Level in Synovial Fluid Is High in Patients with Spondyloarthropathy but Not in Patients with Gout.
10.3346/jkms.2013.28.9.1289
- Author:
Chang Nam SON
1
;
So Young BANG
;
Ji Hae KIM
;
Chan Bum CHOI
;
Tae Hwan KIM
;
Jae Bum JUN
Author Information
1. Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea. junjb@hanyang.ac.kr
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Caspase-1;
Synovial Fluid;
Gout;
Spondyloarthropathies
- MeSH:
Adult;
Aged;
Arthritis, Rheumatoid/enzymology/metabolism/pathology;
Caspase 1/*analysis;
Female;
Gout/*enzymology/metabolism/pathology;
Humans;
Interleukin-18/analysis;
Interleukin-1beta/analysis;
Leukocyte Count;
Male;
Middle Aged;
Osteoarthritis/enzymology/metabolism/pathology;
Spondylarthropathies/*enzymology/metabolism/pathology;
Synovial Fluid/*enzymology/metabolism;
Uric Acid/analysis
- From:Journal of Korean Medical Science
2013;28(9):1289-1292
- CountryRepublic of Korea
- Language:English
-
Abstract:
Activation of caspase-1 by NALP3 inflammasomes has been shown to be important in initiating acute gouty arthritis. The objectives of this study were to measure the levels of caspase-1 in synovial fluid in gout and various arthritides, and to elucidate the clinical significance of caspase-1 levels in synovial fluid. Caspase-1, IL-1beta, IL-18, and uric acid were measured in synovial fluid from 112 patients with gout and other arthritides, such as rheumatoid arthritis, osteoarthritis, and spondyloarthropathy. Caspase-1 in synovial fluid from patients with crystal-induced arthritis, inflammatory arthritis, osteoarthritis, and spondyloarthropathy was 35.9 +/- 86.7, 49.7 +/- 107.7, 2.1 +/- 7.0, and 152.6 +/- 155.7 pg/mL, respectively. The mean level and the frequency of high levels (> or =125 pg/mL) of caspase-1 in spondyloarthropathy were significantly higher than those in the other arthritides including gout. Caspase-1 was detectible in the synovial fluid of patients with the various arthritides. Contrary to our hypothesis, the caspase-1 level in the synovial fluid of patients with gout was not higher than in that of other arthritides. High levels of caspase-1 may be helpful in differentiating spondyloarthropathy from other arthritides.
