KCHO-1, a novel herbal anti-inflammatory compound, attenuates oxidative stress in an animal model of amyotrophic lateral sclerosis.
10.4142/jvs.2017.18.4.487
- Author:
Myung Geun KOOK
1
;
Soon Won CHOI
;
Yoojin SEO
;
Dong Woung KIM
;
Bong Keun SONG
;
Ilhong SON
;
Sungchul KIM
;
Kyung Sun KANG
Author Information
1. Adult Stem Cell Research Center, College of Veterinary Medicine, Seoul National University, Seoul 08826, Korea. kangpub@snu.ac.kr
- Publication Type:Original Article
- Keywords:
amyotrophic lateral sclerosis;
gp91(phox);
neurodegenerative diseases;
oxidative stress;
traditional medicine
- MeSH:
Amyotrophic Lateral Sclerosis*;
Animals*;
Central Nervous System;
Ethanol;
Fatigue;
Inflammation;
Medicine, Traditional;
Mice;
Mice, Transgenic;
Microglia;
Models, Animal*;
Motor Neurons;
Neurodegenerative Diseases;
Neuroglia;
Oxidative Stress*;
Spinal Cord;
Superoxide Dismutase
- From:Journal of Veterinary Science
2017;18(4):487-497
- CountryRepublic of Korea
- Language:English
-
Abstract:
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by selective death of motor neurons in the central nervous system. The main cause of the disease remains elusive, but several mutations have been associated with the disease process. In particular, mutant superoxide dismutase 1 (SOD1) protein causes oxidative stress by activating glia cells and contributes to motor neuron degeneration. KCHO-1, a novel herbal combination compound, contains 30% ethanol and the extracts of nine herbs that have been commonly used in traditional medicine to prevent fatigue or inflammation. In this study, we investigated whether KCHO-1 administration could reduce oxidative stress in an ALS model. KCHO-1 administered to ALS model mice improved motor function and delayed disease onset. Furthermore, KCHO-1 administration reduced oxidative stress through gp91(phox) and the MAPK pathway in both classically activated microglia and the spinal cord of hSOD1(G93A) transgenic mice. The results suggest that KCHO-1 can function as an effective therapeutic agent for ALS by reducing oxidative stress.
