Extracorporeal Life Support in Treatment of Poisoning Patient: Systematic Review.
- Author:
Yong Hee LEE
1
;
Dong Ryul KO
;
Taeyoung KONG
;
Young Seon JOO
;
Je Sung YOU
;
Sung Phil CHUNG
Author Information
1. Department of Emergency Medicine, Yonsei University College of Medicine, Seoul, Korea. emstar@yuhs.ac
- Publication Type:Original Article
- Keywords:
Cardiopulmonary bypass;
Extracorporeal circulation;
Extracorporeal membrane oxygenation;
Poisoning
- MeSH:
Cardiopulmonary Bypass;
Cohort Studies;
Extracorporeal Circulation;
Extracorporeal Membrane Oxygenation;
Heart Arrest;
Hemodynamics;
Humans;
Poisoning*;
Prospective Studies;
Publications;
Research Personnel
- From:Journal of The Korean Society of Clinical Toxicology
2016;14(1):1-8
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Extracorporeal life support (ECLS) is a term used to describe a number of modalities including extracorporeal membrane oxygenation (ECMO) to support cardiac and/or pulmonary systems. The purpose of this study is to review the available evidence regarding the effect of ECLS in patients with acute poisoning. METHODS: Electronic literature searches with PubMed, Embase, Cochrane library, and KoreaMed were conducted for identification of relevant studies addressing ECLS in treatment of acute poisoning. The literature search was conducted by two investigators in March, 2016 with publication language restricted to English and Korean. The toxic substance, technique of ECLS, and final outcome of each case were analyzed. RESULTS: The final analysis included 64 articles including 55 case reports. There were no articles classified according to a high level of evidence such as randomized trial and prospective cohort study. ECLS treatment was used in the management of patients poisoned with 36 unique substances. Venovenous ECMO was performed in 4 cases. Among the reported cases, 10 patients died despite treatment with ECLS. CONCLUSION: Evidence supporting ECLS for patients with acute poisoning is inadequate. However, many case reports suggest that early consideration of ECLS in poisoned patients with refractory cardiac arrest or hemodynamic compromise refractory to standard therapies may be beneficial.
