Evaluation of the Korean Network for Organ Sharing Expanded Donor Criteria in Deceased Donor Renal Transplantation.
10.4285/jkstn.2013.27.4.166
- Author:
Ui Jun PARK
1
;
Won Hyun CHO
;
Hyoung Tae KIM
;
Min Young KIM
;
Yong Lim KIM
;
Chan Duck KIM
;
Jang Hee CHO
;
Young Hoon KIM
;
Suk Joo PARK
;
Sang Young CHUNG
;
Soo Jin Na CHOI
;
Ho Kyun LEE
;
Sung Kwang PARK
;
Sik LEE
;
Hee Chul YU
Author Information
1. Department of Surgery, Keimyung University Dongsan Medical Center, Keimyung University School of Medicine, Daegu, Korea. wh51cho@dsmc.or.kr
- Publication Type:Original Article
- Keywords:
Kidney transplantation;
Expanded criteria;
Standard criteria;
Deceased donor;
Survival rate
- MeSH:
Cause of Death;
Cerebral Infarction;
Creatinine;
Delayed Graft Function;
Graft Survival;
Humans;
Hypertension;
Kidney;
Kidney Transplantation*;
Korea;
Retrospective Studies;
Survival Rate;
Tissue Donors*;
Transplantation, Homologous;
Transplants
- From:The Journal of the Korean Society for Transplantation
2013;27(4):166-173
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: This study was conducted in order to evaluate the propriety of expanded donor criteria in Korea and to identify the preoperative factors influencing allograft survival and function. METHODS: We studied 404 patients who received deceased renal transplants from five transplantation centers of 2, 3 territory from 2000 to 2010. Differences in 1-year graft function, delayed graft function (DGF) rate, and graft survival rate between the standard criteria donor (SCD) and expanded criteria donor (ECD) were compared retrospectively. The preoperative factors influencing graft function and graft survival were analysed. RESULTS: SCD showed significantly better 1-year graft function than ECD (P=0.011). No differences in 1-year acute rejection rate were observed between SCD (13.2%) and ECD (16.9%) (P=0.449). Significantly higher DGF rate was observed for ECD (25.4%) than for SCD (14.1%) (P=0.022). Graft type had no significant influence on 5-year graft survival (SCD 94.5% vs. ECD 93.7%) (P =0.835). Advanced donor age (P=0.001), donor hypertension history (P=0.047), high serum creatinine (P=0.002), and cerebral infarction as cause of death (P=0.004) had a negative influence on 1-year allograft function. Significantly low graft survival was observed for advanced donor age (P =0.002). CONCLUSIONS: Graft function, DGF rates of ECD were poorer than those of SCD. Graft survival rate of ECD was comparable to that of SCD kidney. Korean Network for Organ Sharing expanded criteria may underestimate the organ quality of deceased kidney and modification may be needed in order to expand the potential donor pool through nationwide study.
