Improvement of Pulmonary Function after Administration of Azithromycin in a Patient with Bronchiolitis Obliterans: a Case Report.
10.4046/trd.2008.65.5.410
- Author:
Ji Hye OH
1
;
Kyung Chan KIM
;
Sung Woo KIM
;
Dae Sung HYUN
;
Sang Chae LEE
;
Sung Hwa BAE
;
Kyung Jae JUNG
;
Kun Young KWON
Author Information
1. Department of Internal Medicine, Catholic University of Daegu School of Medicine, Daegu, Korea.
- Publication Type:Case Report
- Keywords:
Bone marrow transplantation;
Bronchiolitis obliterans;
Pulmonary function;
Azithromycin
- MeSH:
Azithromycin;
Biopsy;
Bone Marrow;
Bone Marrow Transplantation;
Bronchiolitis;
Bronchiolitis Obliterans;
Dyspnea;
Female;
Forced Expiratory Volume;
Humans;
Immunosuppressive Agents;
Lung;
Macrolides;
Transplants;
Vital Capacity;
Young Adult
- From:Tuberculosis and Respiratory Diseases
2008;65(5):410-415
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Bronchiolitis obliterans (BO) is a serious noninfectious complication following an allogeneic bone marrow transplant (BMT). A 21-year-old female received an allogeneic BMT as a treatment for myelodyplastic syndrome. Four months after the BMT, progressive dyspnea developed and BO was also diagnosed by a lung biopsy. The patient was administered steroid and immunosuppressive agents for 1 year but there was no improvement in pulmonary function. Azithromycin was prescribed (500 mg q.d. for 3 days followed by 250 mg three time a week) because macrolides might decrease the inflammatory reaction leading to BO. The patient's pulmonary function improved after administration of azithromycin for 1 year. The forced expiratory volume in a one second (FEV1) increase was 220 mL (28.2%) and the forced vital capacity (FVC) increase was 460 mL (25.7%). We report the improvement in the pulmonary function after the administration of azithromycin for 1 year in a patient with BO after a BMT.
