Epidermal Growth Factor Receptor as Predicting Factor on Biochemical Recurrence after Radical Prostatectomy: A Prospective Study.
10.4111/kju.2008.49.11.974
- Author:
Jeong Woo LEE
1
;
Kang Su CHO
;
Kyung Seok HAN
;
Eun Kyoung KIM
;
Jae Young JOUNG
;
Ho Kyung SEO
;
Jinsoo CHUNG
;
Weon Seo PARK
;
Kang Hyun LEE
Author Information
1. Urologic Oncology Clinic, National Cancer Center, Goyang, Korea. uroonco@ncc.re.kr
- Publication Type:Original Article
- Keywords:
Epidermal growth factor receptor;
Prostate cancer;
Biochemical recurrence
- From:Korean Journal of Urology
2008;49(11):974-980
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: We investigated epidermal growth factor receptor(EGFR) expression in prostate cancer(PCa) and their potential role as predicting factor on biochemical recurrence(BCR). MATERIALS AND METHODS: Between February 2005 and February 2007, EGFR expression were prospectively evaluated in a consecutive series of 88 PCa patients with the following characteristics: 66 patients treated with retropubic radical prostatectomy(RRP); 22 patients treated with neoadjuvant hormonal therapy followed by RRP. The relationship between EGFR expression and several clinicopathologic parameters were evaluated. The probability of BCR-free survival was determined using the Kaplan-Meier method. RESULTS: EGFR expression, was evaluated by immunohistochemistry, was found in 31 of 88(35.2%) patients. 8 of 31 EGFR-positive patients(25.8%) had BCR, whereas only 5 of 57 EGFR-negative patients(8.8%) had BCR (p=0.031) during a median follow-up of 21 months. Among several variables, high serum prostate-specific antigen values(>or=20), extraprostatic extension, seminal vesicle invasion, and EGFR expression were the significant predictors of BCR on univariate analysis. But, multivariate analysis showed that no variable was significant predictor of BCR. EGFR-negative patients had a significantly longer mean BCR-free survival time than EGFR-positive patients(p=0.027). CONCLUSIONS: EGFR expression could be an potential predicting factor on BCR following RRP.
