TGF-beta1 Protein Expression in Bullae of Patients with Spontaneous Pneumothorax.
- Author:
Kwang Ho KIM
1
;
Jung Soo CHO
;
Young Sam KIM
;
Yong Han YOON
;
Joung Taek KIM
;
Wan Ki BAEK
;
Lucia KIM
;
Sun U SONG
Author Information
1. Department of Thoracic and Cardiovascular Surgery, College of Medicine, Inha University, Korea.
- Publication Type:Original Article
- Keywords:
Bullae;
Proteins
- MeSH:
Adult;
Female;
Humans;
Lung;
Male;
Pneumothorax*;
Transforming Growth Factor beta1*
- From:The Korean Journal of Thoracic and Cardiovascular Surgery
2006;39(11):805-809
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: In our previous study, we demonstrated that transforming growth factor-beta 1 receptor II (TGF-beta1RII) may have a role in the formation of bullae. In this study, we investigated if expression of transforming growth factor-beta 1 (TGF-beta1) ligand was altered in a bullous lung tissue by immunohistochemical staining of bullous tissues from patients with primary spontaneous pneumothorax. MATERIAL AND METHOD: Bullous lung tissues were obtained from 36 patients with primary spontaneous pneumothorax, including 34 males and 2 females aged 14 to 38 years old. RESULT: Of the 36 patients, 19 were TGF-beta1 positive and 24 were transforming growth factor-beta 1 receptor II (TGF-beta1RII) positive. Among the 19 TGF-beta1 positives, 15 were also TGF-beta1RII positive, observation at high magnification showed that strong immunohistochemical stain was detected in the boundary region between the bullous and normal lung tissues. CONCLUSION: These results suggest that overexpression of TGF-beta1 may be involved in the formation of a bulla as well as the alteration of TGF-beta1RII expression. Further molecular studies are needed to elucidate the more detailed molecular mechanisms of the bulla formation.
