Immunohistochemical Analysis of Pituitary Adenomas according to Endocrinologic Function.
- Author:
Hyun JE
1
;
Jae Hyoo KIM
;
Jung Kil LEE
;
Tae Sun KIM
;
Shin JUNG
;
Soo Han KIM
;
Sam Suk KANG
;
Je Hyuk LEE
;
Min Cheol LEE
Author Information
1. Department of Neurosurgery, Chonnam University Hospital, Kwangju, Korea.
- Publication Type:Original Article
- Keywords:
Pituitary adenoma;
Immunohistochemical staining;
Antigen retrieval system
- MeSH:
Adenoma;
Classification;
Incidence;
Lymphocytes, Null;
Pituitary Neoplasms*
- From:Journal of Korean Neurosurgical Society
1997;26(5):635-640
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
On the bases of the authors analysed 64 cases of pituitary adenoma, endocrinologic manifestations and immunohistochemical staining by both conventional means and the antigen retrieval system. The incidence of each type and there interrelationship was thus demonstrated. The endocrinologic results of 64 cases were as follows: Should the total number of each type of adenoma be included here. Prolactin-secreting adenoma(39.0%), nonfunctioning adenoma(26.6%), and GH-secreting adenoma(17.2%). Conventional immunohistochemical staining revealed the presence of null cell adenoma(48.4%), prolactinoma(21.9%), and GH-secreting adenoma(12.5%). All adenomas shown by conventional immunohistochemical staining to be null cell type were thus reclassified by the antigen retrieval system. On the basis of these results, the authors concluded that for the classification of pituitary adenomas, immunohistochemical staining by the antigen retrieval system is more sensitive than conventional immunohistochemical staining. In addition to avoid false-positive results, EM confirmation is required.
